Cannabis Improves Clinical Outcomes and Quality of Life in Patients With Chronic Pouchitis

Authors

Timna Naftali, MD, Lihi Bar-Lev Schleider, PhD, Hen Kayless, MD, Zohar Bromberg, PhD, Iris Dotan, MD, and Efrat Broide, MD


Published

August 17, 2023

Abstract

Many patients with ulcerative colitis after ileoanal pouch anastomosis report improvement of pouchitis with the use of cannabis. Nine patients with chronic pouchitis used 1 g/d of cannabis: 7 patients were male with average age 51 ± 16 years. Average partial pouchitis disease activity index were 11 (range 8–17), 6 (range 5–8), and 5 (range 4–8); endoscopic subscores were 7 .3 ± 2.3, 6 ± 1.1, and 4.4 ± 0.9; average bowel movements per day were 14 (range 8–20), 8 (range 2–13), and 10 (range 13–8); and quality of life increased from 72 ± 1 to 90 ± 16 and 97 ± 10 (P = 0.001) before cannabis treatment and after 8–12 and 52 weeks, respectively. No adverse events were reported.


DOI: 10.14309/crj.0000000000001131

Citations

Naftali, T., Schleider, L. B. L., Kayless, H., Bromberg, Z., Dotan, I., & Broide, E. (2023). Cannabis Improves Clinical Outcomes and Quality of Life in Patients With Chronic Pouchitis. ACG Case Reports Journal, 10(8).