Cannabinoids in Urology. Which Benign Conditions Might They Be Appropriate to Treat: A Systematic Review

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Authors: Brian Robert Peter Birch, Charlie Taylor Published in Urology November 2020 Abstract There is growing evidence suggesting cannabinoids may provide suitable alternatives to conventional treatments in an increasing number of clinical settings. This review evaluates how cannabinoids are used to treat certain benign urologicalpathologies and to clarify the clinical value of this data. This…

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FURTHER EVIDENCE OF ANXIETY- AND DEPRESSION-LIKE BEHAVIOR FOR TOTAL GENETIC ABLATION OF CANNABINOID RECEPTOR TYPE 1

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Authors: Delia Soriano, Alicia Brusco, Laura Caltana Published in Behavioural Brain Research November 2020 Abstract Cannabinoid receptor type 1 (CB1R) is the most abundant cannabinoid receptor in central nervous system. Clinical studies and animal models have shown that the attenuation of endocannabinoid system signaling correlates with the development of psychiatric disorders such as anxiety, depression…

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Cannabis Medicines & the World Health Organization

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A video update from Kenzi Riboulet-Zemouli and Michael Krawitz on the World Health Organization’s recommendations on cannabis scheduling and international cannabis law.

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Cannabis Use May Reduce Healthcare Utilization and Improve Hospital Outcomes in Patients with Cirrhosis

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Authors: Lindsay A. Sobotka, Khalid Mumtaz, Alice Hinton, Sean G. Kelly, Lanla F. Conteh, Anthony J. Michaels, A. James Hanje, Michael R. Wellnera Published in Annals of Hepatology November 2020 Abstract Introduction and Objectives:  Previous studies reveal conflicting data on the effect of cannabis use in patients with cirrhosis. This research evaluates the impact of…

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Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression

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Authors: Jianfeng Wang, Yunze Xu, Yun Zou, Liangsong Zhu, Baijun Dong, Jiwei Huang, Yonghui Chen, Wei Xue, Yiran Huang, Wen Kong & Jin Zhang Published in Tumor Biology October 2016 Abstract Renal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis. Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently…

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Marijuana and Cannabinoids in ESRD and Earlier Stages of CKD

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Authors: Joshua L. Rein, Christina M. Wyatt Published in American Journal of Kidney Diseases August 2017 Abstract Marijuana is the most commonly used recreational drug in the United States, and legal recreational and medicinal use has gained public acceptance during the last decade. Twenty-nine US states have established medical marijuana programs, 8 of which have also…

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Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

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Authors: Partha Mukhopadhyaya, Mohanraj Rajesha, Hao Pan, Vivek Patel, Bani Mukhopadhyaya, Sándor Bátkai, Bin Gao, György Haskóc, Pál Pachera Published in Journal of Pain and Symptom Management February 2010 Abstract Cisplatin is an important chemotherapeutic agent; however, its nephrotoxicity limits its clinical use. Enhanced inflammatory response and oxidative/nitrosative stress seem to play a key role in…

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Nephrologist Views Regarding Cannabinoid Use in Advanced Chronic Kidney Disease and Dialysis: A Survey

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Authors: David Collister, MD, PhD, Karthik Tennankore, MD, SM, Sara N. Davison, MD, MHSc, Ron Wald, MD, MPH, Christian Rabbat, MD, MSc, Michael Walsh, MD, PhD Published in Journal of Pain and Symptom Management August 2020 Abstract Context: The efficacy and safety of cannabinoids to treat symptoms in individuals with kidney disease is uncertain. Objectives: We sought to…

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Cannabigerol (CBG) Survey Study

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A team of cannabis researchers is investigating the use of cannabis containing the cannabinoid cannabigerol (CBG) and people’s experiences with it.

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Cannabinoid-2 receptor activation ameliorates hepatorenal syndrome

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Authors: Eszter Trojnar, Katalin Erdelyi,Csaba Matyas, Suxian Zhao, Janos Paloczi, Partha Mukhopadhyay, Zoltan V.Varga, Gyorgy Hasko, Pal Pacher Published in Free Radical Biology and Medicine May 2020 Abstract Study rationale: Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage liver disease characterized by the rapid decline of kidney function. Herein, we explored the therapeutic potential of…

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Prescribed medical cannabis in women with gynecologic malignancies: A single-institution survey-based study

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Authors: Emily M.Webster, Ghanshyam S.Yadav, Stefan Gysler, Blair McNamara, Jonathan Black, Joan Tymon-Rosario, Burak Zeybek, Chanhee Han, Christopher K. Arkfeld, Vaagn Andikyan, Gulden Menderes, Gloria Huang, Masoud Azodi, Dan-Arin Silasi, Alessandro D.Santin,Peter E.Schwartz, Elena S.Ratner, Gary Altwerger Published in Gynecologic Oncology Reports   November 2020 Abstract Research within a gynecologic oncology population has lagged behind…

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Signaling Through the Type 2 Cannabinoid Receptor Regulates the Severity of Acute and Chronic Graft versus Host Disease

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Authors: Cheng Yin Yuan, Vivian Zhou, Garrett Sauber, Todd M Stollenwerk, Richard Komorowski, Alicia López, Rosa Maria Tolon, Julian Romero, Cecilia J Hillard, William R Drobyski Published in Blood  October 2020 Abstract Graft versus host disease (GVHD) pathophysiology is a complex interplay between cells that comprise the adaptive and innate arms of the immune system….

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