Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A Systematic Review

Author: Eduardo Orrego-González, Luisa Londoño-Tobón, José Ardila-González, Diego Polania-Tovar, Ana Valencia-Cárdenas and Alberto Velez-Van Meerbeke Published in Hindawi July 2020 Abstract Objectives Colorectal cancer represents a heavy burden for health systems worldwide, being the third most common cancer worldwide. Despite the breakthroughs in medicine, current chemotherapeutic options continue to have important side effects and may not…

Association Between Recent Cannabinoid Use and Acute Ischemic Stroke

Author: Carmela V. San Luis, Christa O’Hana S. Nobleza, Shashank Shekhar, Rebecca Sugg, Darren J. Villareal, Tapan Mehta, Shreyas Gangadhara Published in Frontiers in Psychology June 2020 Abstract Objectives Studies that have analyzed the association between cannabis use and acute ischemic stroke have provided conflicting results. In this study, we aim to determine the association of…

Totality of the Evidence Suggests Prenatal Cannabis Exposure Does Not Lead to Cognitive Impairments: A Systematic and Critical Review

Author: Ciara A. Torres, Christopher Medina-Kirchner, Kate Y. O’Malley, and Carl L. Hart Published in Frontiers in Psychology May 2020 Abstract Background Despite limited data demonstrating pronounced negative effects of prenatal cannabis exposure, popular opinion and public policies still reflect the belief that cannabis is fetotoxic. Methods This article provides a critical review of results from…

Cannabis and Psychosis: a Critical Overview of the Relationship

Authors: Charles Ksir, Carl L Hart Published in Current Psychiatry Reports February 2016 Abstract Interest in the relationship between cannabis use and psychosis has increased dramatically in recent years, in part because of concerns related to the growing availability of cannabis and potential risks to health and human functioning. There now exists a plethora of scientific…

Cannabis Nurses Share Info from the Front Lines

How does Cannabis Nursing address the booming need for education and worldwide support for cannabis medicine? The Society of Cannabis Clinicians interviewed three Cannabis Nurses to gain insight.

Medical Cannabis for the Treatment of Fibromyalgia

Author: George Habib, Suheil Artul Published in Journal of Clinical Rheumatology August 2018 Abstract Background Background: Fibromyalgia is a chronic pain syndrome, characterized by chronic musculoskeletal pain, fatigue, and mood disturbances. There are nearly no data on the effect of medical cannabis (MC) treatment on patients with fibromyalgia. Methods Data were obtained from the registries of…

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Author: Eric P. Baron DO Published in HEADACHE Journal of Headache and face pain August 2018 Abstract Background Comprehensive literature reviews of historical perspectives and evidence supporting cannabis/cannabinoids in the treatment of pain, including migraine and headache, with associated neurobiological mechanisms of pain modulation have been well described. Most of the existing literature reports on the…

Antibacterial Cannabinoids from Cannabis Sativa: A Structure-Activity Study

Authors: Giovanni Appendino, Simon Gibbons, Anna Giana, Alberto Pagani, Gianpaolo Grassi, Michael Stavri, Eileen Smith,and M. Mukhlesur Rahman Published in Journal of Natural Products August 2008 Abstract Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene…

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid

Authors: Francesca Borrelli, Ester Pagano, Barbara Romano, Stefania Panzera, Francesco Maiello, Diana Coppola, Luciano De Petrocellis, Lorena Buono, Pierangelo Orlando, Angelo A. Izzo Published in Oxford Academic September 2014 Abstract Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor potential (TRP) M8…

Medical Cannabis for the Treatment of Fibromyalgia

Authors: George Habib, Suheil Artul Published in Journal of Clinical Rheumatology August 2018 Abstract Background Fibromyalgia is a chronic pain syndrome, characterized by chronic musculoskeletal pain, fatigue, and mood disturbances. There are nearly no data on the effect of medical cannabis (MC) treatment on patients with fibromyalgia. Methods Data were obtained from the registries of 2…

A Scoping Review of the Use of Cannabis and Its Extracts as Potential Harm Reduction Strategies: Insights from Preclinical and Clinical Research

Authors: James Siklos-Whillans, Alia Bacchus, Laurie A. Manwell Published in International Journal of Mental Health and Addiction March 2020 Abstract Cannabis as a harm reduction strategy (HRS) is supported by evidence demonstrating its efficacy for pain relief and as a substitution for alcohol, illicit drugs, and pharmaceuticals. Animal models show cannabinoids reduce the effects of opiate…

Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders

Authors: María Fernández-Trapero, Carmen Pérez-Díaz, Francisco Espejo-Porras, Eva de Lago, Javier Fernández-Ruiz Published in Biomolecules February 2020 Abstract The phytocannabinoid-based medicine Sativex® is currently marketed for the treatment of spasticity and pain in multiple sclerosis patients and is being investigated for other central and peripheral pathological conditions. It may also serve in Veterinary Medicine for the…