Frequent Cannabis Use and Cessation of Injection of Opioids, Vancouver, Canada, 2005-2018

Authors: Hudson Reddon, Kora DeBeck, M Eugenia Socias, Stephanie Lake, Huiru Dong, Mohammad Karamouzian, Kanna Hayashi, Thomas Kerr, M-J Milloy Published in American Journal of Public Health August 2020 Abstract Objectives To evaluate the impact of frequent cannabis use on injection cessation and injection relapse among people who inject drugs (PWID). Methods Three prospective cohorts…

A molecular basis for the anti-inflammatory and anti-fibrosis properties of cannabidiol

Authors: Falone Sunda, Afolake Arowolo Published in The FASEB Journal April 2020 Abstract Cannabidiol (CBD) is considered a non-psychoactive, antioxidant, and anti-inflammatory compound derived from the Cannabis sativa plant. There are various reports on the versatile function of CBD, including ameliorating chronic inflammation and fibrosis formation in several tissue types. However, only a hand full…

Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome

Authors: Gil Bar-Sela, Cohen Idan, Salvatore Campisi-Pinto, Gil M Lewitus Published in Cancers August 2020 Abstract Cannabis or its derivatives are widely used by patients with cancer to help with cancer symptoms and treatment side effects. However, cannabis has potent immunomodulatory properties. To determine if cannabis consumption during immunotherapy affects therapy outcomes, we conducted a…

Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment

Authors: Viola Brugnatelli, Fabio Turco, Ulderico Freo and Gastone Zanette Published in Frontiers in Neuroscience April 2020 Introduction Irritable Bowel Syndrome (IBS) is a functional disorder characterized by abdominal pain, spasms, and altered bowel movements, either predominantly diarrhea (IBS-D), or predominantly constipation (IBS-C), or alternating between those states (Saha, 2014). In the Western world it…

A molecular basis for the anti‐inflammatory and anti‐fibrosis properties of cannabidiol

Authors: Falone Sunda, Afolake Arowolo Published in The FASEB Journal September 2020 Abstract Cannabidiol (CBD) is considered a non‐psychoactive, antioxidant, and anti‐inflammatory compound derived from the Cannabis sativa plant. There are various reports on the versatile function of CBD, including ameliorating chronic inflammation and fibrosis formation in several tissue types. However, only a hand full…

The present status of artisanal cannabis for the treatment of epilepsy in the United States.

Authors: Dustin Sulak, Russell Saneto, Bonni Goldstein Published in Epilepsy & Behavior May 2017 Abstract The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a position to monitor and guide the use of herbal cannabis in epilepsy patients. We report…

Fibromyalgia and the endocannabinoid system

Authors: John M. McPartland Published in Science Direct November 2009 Introduction Fibromyalgia has been characterized as an ‘endocanna- binoid (eCB) deficiency syndrome’, along with other refractory maladies such as irritable bowel syndrome, migraine, premenstrual syndrome and other pain- processing disorders (Russo 2004). This syndrome may arise from diminished receptor expression, inadequate ligand biosynthesis or gain-of-function…

Cannflavins – From plant to patient: A scoping review

Authors: Simon Erridge, Nagina Mangal, Oliver Salazar, Barbara Pacchetti, Mikael H.Sodergren Published in Fitoterapia October 2020 Abstract Introduction Cannflavins are a group of prenylflavonoids derived from Cannabis sativa L.. Cannflavin A (CFL-A), B (CFL-B) and C (CFL-C) have been heralded for their anti-inflammatory properties in pre-clinical evaluations. This scoping review aims to synthesise the evidence…

Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK

Authors: Young Sun Hwang, Youn-Jung Kim, Mi Ok Kim, Mingyeong Kang, Sae Woong Oh, Youn Hwa Nho, See-Hyoung Park, Jongsung Lee Published in Science Direct August 2017 Abstract Melanogenesis plays a critical role in the protection of skin against external stresses such as ultraviolet irradiation and oxidative stressors. This study was aimed to investigate the…

Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients

Authors: Jeffrey Y. Hergenrather, Joshua Aviram, Yelena Vysotski, Salvatore Campisi-Pinto, Gil M. Lewitus, David Meiri Published in Rambam Maimonides Medical Journal January 2020 Abstract Objective The aim of this cross-sectional questionnaire-based study was to identify associations between the doses of cannabinoids and terpenes administered, and symptoms of attention deficit hyperactivity disorder (ADHD). Methods: Participants were adult patients…

Cannabis Nurses Answer Common Patient Inquiries

The SCC hears from three seasoned Cannabis Nurses as they share their insight on modes of administration, patient access, and adversity to the cannabis “high”.

Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples

Authors: Kumar Vasudevan & Veronica Stahl Published in Journal of Cannabis Research June 2020 Abstract Background Dental plaque is a global health problem affecting people of various age groups. Cannabinoids are gaining enormous research attention due to its beneficial properties for various applications. A preliminary observation on antimicrobial property of cannabinoids against dental plaque bacteria has…