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Medical Cannabis Treatment for Chronic Pain: Outcomes and Prediction of Response

Authors: Joshua Aviram, Dorit Pud, Tamar Gershoni, Bareket Schiff‐Keren, Miriam Ogintz, Simon Vulfsons, Tamar Yashar, Adahan Haim‐Moshe, Silviu Brill, Howard Amital, Itay Goor‐Aryeh, Dror Robinson, Leslie Green, Refael Segal, Yacov Fogelman, Oren Tsvieli, Ben Yellin, Yelena Vysotski, Ofir Morag, Vadim Tashlykov, Roee Sheinfeld, Ruth Goor, David Meiri, Elon Eisenberg Published in European Journal of Pain…

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Preliminary Assessment of Medical Cannabis Consumption by Cancer Survivors

Authors: Yuval Zolotova, Lia Eshet, Ophir Moragb Published in Complementary Therapies in Medicine October 2020 Abstract Objectives To assess the motivation of cancer survivors to consume medical cannabis and to assess the patterns of use, perceived efficacy, as well as side and adverse effects. Methods Cross-sectional survey among 190 Israeli cancer survivors who were licensed…

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Add-on cannabidiol significantly decreases seizures in 3 patients with SYNGAP1 developmental and epileptic encephalopathy

Authors: Mathieu Kuchenbuch, Gianluca D’Onofrio, Nicole Chemaly, Giulia Barcia, Théo Teng, Rima Nabbout Published in Epilepsia Open July 2020 Abstract Mutations in SYNGAP1 are associated with developmental delay, epilepsy, and autism spectrum disorder (ASD). Epilepsy is often drug-resistant in this syndrome with frequent drop attacks. In a prospective study of add-on cannabidiol (CBD), we identified…

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Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production

Authors: William Becker, Haider Rasheed Alrafa,Kiesha Wilson, Kathryn Miranda, Courtney Culpepper, Ioulia Chatzistamou, Guoshuai Cai, Mitzi Nagarkatti, Prakash S. Nagarkatti Published in Iscience August 2020 Abstract Summary Intestinal disequilibrium leads to inflammatory bowel disease (IBD), and chronic inflammation predisposes to oncogenesis. Antigen-presenting dendritic cells (DCs) and macrophages can tip the equilibrium toward tolerance or pathology….

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A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

Authors: Cathy Davies, Robin Wilson, Elizabeth Appiah-Kusi, Grace Blest-Hopley, Michael Brammer, Jesus Perez, Robin M Murray, Paul Allen, Matthijs G Bossong, Philip McGuire, Sagnik Bhattacharyya Published in Translational Psychiatry September 2020 Abstract Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis (CHR) and are associated with altered neural responses to…

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Cannabidiol Modulates Cytokine Storm in Acute Respiratory Distress Syndrome Induced by Simulated Viral Infection Using Synthetic RNA

Authors: Hesam Khodadadi, Évila Lopes Salles, Abbas Jarrahi, Fairouz Chibane, Vincenzo Costigliola, Jack C Yu, Kumar Vaibhav, David C Hess, Krishnan M Dhandapani, Babak Baban Published in Cannabis and Cannabinoid Research September 2020 Abstract Introduction In the absence of effective antivirals and vaccination, the pandemic of COVID-19 remains the most significant challenge to our health…

Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens

Authors: Melissa Ellermann, Alline R. Pacheco, Angel G. Jimenez, Regan M. Russell, Santiago Cuesta, Aman Kumar, Wenhan Zhu, Gonçalo Vale, Sarah A. Martin, Prithvi Raj, Jeffrey G. McDonald, Sebastian E. Winter, Vanessa Sperandio Published in Cell October 2020 Abstract Summary Endocannabinoids are host-derived lipid hormones that fundamentally impact gastrointestinal (GI) biology. The use of cannabis…

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

Authors: Vincenzo Di Marzo, PhD Published in DIALOGUES IN CLINICAL NEUROSCIENCE 2020 Abstract The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB1 and CB2 receptors. Its expansion to include several eCB-like lipid mediators, their metabolic enzymes, and their molecular targets, forms the endocannabinoidome (eCBome). This complex signaling…

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Neurobiology of cannabinoid receptor signaling

Authors: Beat Lutz, PhD Published in DIALOGUES IN CLINICAL NEUROSCIENCE 2020 Abstract The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous system. Despite its widespread localization, its functions within the context of distinct neural processes are very well discernable and specific. This is remarkable, and the question remains as to how…

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Cannabidiol in conjunction with clobazam: analysis of four randomized‐controlled trials

Authors: Boudewijn Gunning, Maria Mazurkiewicz‐Beldzinska, Richard F.M. Chin, Hari Bhathal Charlotte Nortvedt, Eduardo Dunayevich, Daniel Checketts Published in Acta Neurologica Scandinavica September 2020 Abstract Objectives To assess the efficacy and safety profile of add‐on cannabidiol (CBD) in patients with Lennox‐Gastaut syndrome (LGS) and Dravet syndrome (DS) on clobazam and in the overall population of four…

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A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extracts as complementary therapy: a case report

Authors: Juliana Andrea Ponton, Kim Smyth, Elias Soumbasis, Sergio Andres Llanos, Mark Lewis, Wilhelm August Meerholz & Robert Lawrence Tanguay Published in Journal of Medical Case Reports September 2020 Abstract   Background The pharmacological treatment for autism spectrum disorders is often poorly tolerated and has traditionally targeted associated conditions, with limited benefit for the core…