Experiences with Administration of Marihuana to Glaucoma Patients

Author: Robert S. HeplerRobert J. Petrus Published in Springer Link  1976 Abstract In 1971 Hepler and Frank reported reduction in intraocular pressure occurring after healthy young adults smoked marihuana. These initial observations led to additional studies designed to compare the pressure-reducing effects of placebo, smoked marihuana, and injected THC. Consistent, statistically-significant pressure reduction was observed in…

Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol

Author: Brenda K.Colasanti, Charles R. Craig, R. David Allara Published in Science Direct September 1984 Abstract Cannabinol or cannabigerol was administered to cats topically in doses of 250, 500 and 1000 μg as a single drop or chronically via osmotic minipumps (20 μg hr−1) over a period of 9 days. While cannabinol had a modest…

Finding of endocannabinoids in human eye tissues: Implications for glaucoma

Author: June Chen, Isabel Matias, Tim Dinh, Ta Lu, Sonia Venezia, Amelia Nieves, David F. Woodward, Vincenzo Di Marzo Published in Science Direct May 2005 Abstract Cannabinoid CB1 receptors are involved in ocular physiology and may regulate intraocular pressure (IOP). However, endocannabinoid levels in human ocular tissues of cornea, iris, ciliary body, retina, and choroid from…

The Endocannabinoid System as a Therapeutic Target in Glaucoma

Author: Elizabeth A. Cairns,1 William H. Baldridge,2,3 and Melanie E. M. Kelly Published in Hindawi January 2016 Abstract Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The…

Δ9‐Tetrahydrocannabinolic acid alleviates collagen‐induced arthritis: Role of PPARγ and CB1 receptors

Author: Belén Palomares Martín Garrido‐Rodriguez Claudia Gonzalo‐Consuegra María Gómez‐Cañas Suwipa Saen‐oon Robert Soliva Juan A. Collado Javier Fernández‐Ruiz Gaetano Morello Marco A. Calzado Giovanni Appendino Eduardo Muñoz Published in British Pharmacological Society  June 2020 Abstract Background and Purpose Δ9‐Tetrahydrocannabinolic acid (Δ9‐THCA‐A), the precursor of Δ9‐THC, is a non‐psychotropic phytocannabinoid that shows PPARγ agonist activity. Here, we investigated…

A national survey of US emergency medicine physicians on their knowledge regarding state and federal cannabis laws.

Author: Kevin M. Takakuwa, Frances S. Shofer, and Raquel M. Schears. Published in Mary Ann Liebert, Inc, Publishers February 2020 Abstract Introduction Medical cannabis laws have been passed in 33 U S States but cannabis remains federally illegal Eleven states additionally allow for adult use recreational Studies report and increase in Emergency Department ED use when…

The Impact of Medical Cannabis on Intermittent and Chronic Opioid Users with Back Pain: How Cannabis Diminished Prescription Opioid Usage

Author: Kevin M. Takakuwa, Jeffrey Y. Hergenrather, Frances S. Shofer, and Raquel M. Schears Published in Mary Ann Liebert, Inc. Publishers January 2020 Abstract Objectives: To determine if cannabis may be used as an alternative or adjunct treatment for intermittent and chronic prescription opioid users. Design: Retrospective cohort study. Setting: A single-center cannabis medical practice site…

What is Exo-THC?

Dr. Patricia Frye, SCC Board Member and Director of Takoma Park Integrative Care, asks Christopher Hudalla, Ph. D. of Proverde Labs about Exo-THC.

Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples

Author: Kumar Vasudevan & Veronica Stahl Published in The Journal of Cannabis Research June 2020 Abstract Background  Dental plaque is a global health problem affecting people of various age groups. Cannabinoids are gaining enormous research attention due to its beneficial properties for various applications. A preliminary observation on antimicrobial property of cannabinoids against dental plaque bacteria…

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort

Author: Eric P. Baron, Philippe Lucas, Joshua Eades & Olivia Hogue Published in The Journal of Headache and Pain May 2018 Abstract Background  Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthritis and…

Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A Systematic Review

Author: Eduardo Orrego-González, Luisa Londoño-Tobón, José Ardila-González, Diego Polania-Tovar, Ana Valencia-Cárdenas and Alberto Velez-Van Meerbeke Published in Hindawi July 2020 Abstract Objectives Colorectal cancer represents a heavy burden for health systems worldwide, being the third most common cancer worldwide. Despite the breakthroughs in medicine, current chemotherapeutic options continue to have important side effects and may not…

Association Between Recent Cannabinoid Use and Acute Ischemic Stroke

Author: Carmela V. San Luis, Christa O’Hana S. Nobleza, Shashank Shekhar, Rebecca Sugg, Darren J. Villareal, Tapan Mehta, Shreyas Gangadhara Published in Frontiers in Psychology June 2020 Abstract Objectives Studies that have analyzed the association between cannabis use and acute ischemic stroke have provided conflicting results. In this study, we aim to determine the association of…