Daniel J. Kruger, Ph.D, Carlton CB Bone , M.S, Meredith C. Meacham , Ph.D., M.P.H, Charles Klein , J.D., Ph.D & Jessica S. Kruger , M.S.H.E., Ph.D


June 29,  2023


There is a growing interest in semi-synthetic cannabinoids, including THC-O-acetate (THC-Oac). Some cannabis marketers and users have claimed that THC-Oac produces psychedelic effects; the current study is the first to examine this claim. Researchers developed an online survey for THC-Oac consumers based on previous cannabis and psychedelic use surveys and in consultation with the moderator of an online forum. The survey assessed the experiential profile of THC-Oac and included items from the Mystical Experience Questionnaire (MEQ), an instrument for assessing psychedelic experiences. Participants reported a low to moderate level of cognitive distortions (altered sense of time, difficulties concentrating, difficulties with short-term memory) and few visuals or hallucinations. Participants’ responses were significantly below the threshold for a complete mystical experience on all four MEQ dimensions. Participants who had used classic (5-HT2A agonist) psychedelics had lower scores on all MEQ dimensions. When asked directly, 79% responded that using THC-Oac is “not at all” or “a little” of a psychedelic experience. Some reports of psychedelic experiences may be due to expectations or contaminants. Those having prior experience with classic psychedelics had lower ratings of mystical experiences.

DOI: 10.1080/02791072.2023.2230573


Kruger, D. J., Bone, C. C., Meacham, M. C., Klein, C., & Kruger, J. S. (2023). THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid. Journal of Psychoactive Drugs, 1-5