Cannabidiol (CBD) has been gaining increased attention in contemporary society but seems to have been little explored in dentistry. This scoping review mapped the scientific and technological scenarios related to the use of CBD in dentistry. Peer-reviewed publications were searched in five international databases, patents were searched in five technological platforms. In total, 11 articles and 13 patents involving CBD in dentistry-related applications were included. The countries contributing to most articles were Brazil (27.3%) and USA (18.2%). The studies involved experiments on animals (63.6%) and/or using bacteria or cells (36.4%), and no clinical study was found.
Herbal teas of fiber-type hemp varieties (Cannabis sativa L.) rich in cannabidiolic acid (CBDA) and cannabidiol (CBD) and poor in Δ9-tetrahydrocannabinol acid (THCA) and Δ9-tetrahydrocannabinol (THC) are very popular today. The conditions for preparing herbal infusions are not well standardized and analysis of the lipophilic cannabinoids in infusions is difficult. Therefore, we analyzed the hemp leaf residues after tea preparation by using a response surface modelling approach to estimate the effects of variations in temperature, water volume and extraction time on the residual content of five cannabinoids (CBDA, CBD, THCA, THC, cannabinol (CBN)) in the hemp leaves after extraction.
The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD induces interferon expression and up-regulates its antiviral signaling pathway.
Some men worry that they are not manly enough, and wonder if a lack of testosterone is the reason. Others comment, like a reader recently did, on the age-old fearmongering, unscientific propaganda about Cannabis (specifically THC) that it is a “potent suppressor of testosterone.”
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dosage-limited oxaliplatin-related toxicity. To date, there are no successful interventions for CIPN prevention or treatment.
Cannabis is commonly used among people who drink alcohol, but evidence suggests a nuanced relationship between alcohol consumption and cannabis use. In particular, among individuals undergoing alcohol treatment the impact of cannabis on alcohol intake may depend upon cannabis use frequency.
Medical cannabis use is increasing rapidly in the past several years, with older adults being the fastest growing group. Nevertheless, the evidence for cardiovascular safety of cannabis use is scarce. The aim of this study was to assess the effect of cannabis on blood pressure, heart rate, and metabolic parameters in older adults with hypertension.
Authors: Beat Lutz, PhD Published in DIALOGUES IN CLINICAL NEUROSCIENCE 2020 Abstract The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous system. Despite its widespread localization,…
Author: Kumar Vasudevan & Veronica Stahl Published in The Journal of Cannabis Research June 2020 Abstract Background Dental plaque is a global health problem affecting people of various age groups. Cannabinoids…
Molecular Aspects of Medicine, December 2018
Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid sy…
PLoS One, 1 April 2014
Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level). As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more…
Neuropsychopharmacology, August 2010
Worldwide cannabis dependence is increasing, as is the concentration of Delta(9)-tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the second most abundant cannabinoid in street cannabis, cannabidiol (CBD), is decreasing. These two cannabino…