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Efficacy and usability of a cannabidiol-infused tampon for the relief of primary dysmenorrhea


Valentina Milanova, Kalina Mihaylova, Iva Lazarova, Teodora Georgieva, Harold Baxter, Dafina Dobreva


March 2024


This study aimed to assess efficacy and usability of Cannabidiol (CBD) infused tampons for the relief of primary dysmenorrhea, a condition affecting 50–95% assigned female at birth. While primary dysmenorrhea affects a significant percentage of females, there remains a notable absence of specialized medications or devices to alleviate the intense pain that hinders daily activities. We have developed a CBD-infused tampon, lubricated for comfort and ease, recognising the potential benefits of cannabinoids in pain management.

Materials and methods
A randomized, single-blinded, placebo-controlled, non-interventional study was conducted with 63 participants, screened against an inclusion and exclusion criteria, following a review of their medical history, gynecological examination, and confirmation of the absence of pregnancy and sexually transmitted infections (STIs). Out of 114 screened individuals, 83 were eligible. Participants self-reported their pain levels and satisfaction with the CBD tampon using a modified Mankoski scale (1–10) for pain assessment.

63 participants completed the study, following through three consecutive menstruations. The CBD-infused tampon achieved statistically significant pain reduction during the first and third months of the study (p < 0.05). Less than 5% of participants experienced CBD-infused tampon-related irritation. Between 37 and 40% of the participants reported improvement in the level of vaginal dryness.

This study supports the efficacy and usability of the CBD-infused tampon. The findings indicate the potential of CBD-infused tampons as a promising option for managing menstrual pain. Further research and exploration of this innovative product can contribute to the management of primary dysmenorrhea.

DOI: 10.1016/j.jeud.2023.100057


Milanova, V., Mihaylova, K., Lazarova, I., Georgieva, T., Baxter, H., & Dobreva, D. (2023). Efficacy and Usability of a Cannabidiol-Infused Tampon for the Relief of Primary Dysmenorrhea. Journal of Endometriosis and Uterine Disorders, 100057.