Claire Wang1 Azfer Usmani2 James J. Rucker, Simon Erridge, Carl Holvey, Ross Coomber, Mohammed Sajad, Rahul Guru,Wendy Holden Michael W. Platt, Mikael H. Sodergren
April 27, 2023
Introduction: There are limited therapeutic options for individuals with fibromyalgia. The aim of this study is to analyze changes in health-related quality of life and incidence of adverse events of those prescribed cannabis-based medicinal products (CBMPs) for fibromyalgia.
Methods: Patients treated with CBMPs for a minimum of 1 month were identified from the UK Medical Cannabis Registry. Primary outcomes were changes in validated patient-reported outcome measures (PROMs). A p-value of <.050 was deemed statistically significant.
Results: In total, 306 patients with fibromyalgia were included for analysis. There were improvements in global health-related quality of life at 1, 3, 6, and 12 months (p < .0001). The most frequent adverse events were fatigue (n = 75; 24.51%), dry mouth (n = 69; 22.55%), concentration impairment (n = 66; 21.57%), and lethargy (n = 65; 21.24%).
Conclusion: CBMP treatment was associated with improvements in fibromyalgia- specific symptoms, in addition to sleep, anxiety, and health-related quality of life. Those who reported prior cannabis use appeared to have a greater response. CBMPs were generally well-tolerated. These results must be interpreted within the limitations of study design.
Wang, C., Erridge, S., Holvey, C., Coomber, R., Usmani, A., Sajad, M., … & Sodergren, M. H. (2023). Assessment of clinical outcomes in patients with fibromyalgia: Analysis from the UK Medical Cannabis Registry. Brain and Behavior, e3072.