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Cancer

Russo’s Grand Unified Theory

By | Alzheimer's Disease, Brain Trauma, Cancer, Conditions, Epilepsy, News, Parkinson's, Research, Research Articles

Ethan Russo forwards his paper, Grand Unified Theory (GUT): The Endcannabinoid System, Cannabis and the Microbiome just published in Frontiers of Integrative Neuroscience. Russo notes:

“This article addresses five critical areas of clinical neurology practice wherein conventional medicine has fallen short: epilepsy, brain tumors, Parkinson disease, Alzheimer disease, traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE), and how cannabis-based treatment and nutritional approaches with prebiotics and probiotics may provide more effective treatment.”

The paper, which will be the basis of Russo’s talk at the CannMed conference in LA October 23, begins with this overview:

Neurological therapeutics have been hampered by its inability to advance beyond symptomatic treatment of neurodegenerative disorders into the realm of actual palliation, arrest or reversal of the attendant pathological processes. While cannabis-based medicines have demonstrated safety, efficacy and consistency sufficient for regulatory approval in spasticity in multiple sclerosis (MS), and in Dravet and Lennox-Gastaut Syndromes (LGS), many therapeutic challenges remain. This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). Current basic science and clinical investigations support the safety and efficacy of such interventions in treatment of these currently intractable conditions, that in some cases share pathological processes, and the plausibility of interventions that harness endocannabinoid mechanisms, whether mediated via direct activity on CB1 and CB2(tetrahydrocannabinol, THC, caryophyllene), peroxisome proliferator-activated receptor-gamma (PPARγ; THCA), 5-HT1A (CBD, CBDA) or even nutritional approaches utilizing prebiotics and probiotics. The inherent polypharmaceutical properties of cannabis botanicals offer distinct advantages over the current single-target pharmaceutical model and portend to revolutionize neurological treatment into a new reality of effective interventional and even preventative treatment. Read More

Cannabinoids and Liver Cancer

By | Cancer, Research Articles

Cannabinoids and Liver CancerHepatocellular carcinoma (HCC) is the leading cause of cancer‐associated mortality worldwide; however, only limited therapeutic treatments are currently available. The present study aimed to investigate the effects of cannabinoids as novel therapeutic targets in HCC. In addition, the mechanism underlying the effects of a synthetic cannabinoid, WIN55, 212‐2, on the BEL7402 HCC cell line was investigated. These results provided a basis for the application of WIN in the treatment of HCC. Read More

Cannabidiol Inhibits Human Glioma Cell Migration

By | Brain Health, Cancer, CBD, Research Articles

CaCannabidiol Inhibits Human Glioma Cell MigrationIn 2005, the British Journal of Pharmacology published a study evaluating the ability of cannabidiol (CBD) to impair the migration of tumor cells and thus act as a potential antitumoral compound. The results of the study reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. This antimigratory property, together with the known antiproliferative and apoptotic features of CBD, strengthen the evidence for its use as a potential antitumoral agent.
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Anandamide Inhibits Breast Tumor-Induced Angiogenesis

By | Anandamide, Breast Cancer, Cancer, Endocannabinoid System, Research Articles

Anandamide Inhibits Breast Tumor-Induced AngiogenesisEndocannabinoid Anandamide and Breast Cancer – more evidence. This 2014 study out of Italy, published in the journal Translational Medicine, found that following anandamide treatment, MDA-MB-231 cells lose their ability to stimulate endothelial cells proliferation in vitro, due to a significant inhibition of all the pro-angiogenic factors produced by these cells. This finding adds another piece of evidence to the anti-tumor efficacy of anandamide in breast cancer. Read More

THC Reduces Human Breast Cancer Cell Proliferation

By | Breast Cancer, Cancer, Research Articles, THC
THC Reduces Human Breast Cancer Cell Proliferation THC and breast cancer – Little is known about the effect of cannabinoids on the cell cycle, the main process controlling cell fate. This study out of Spain, published in a 2006 issue of Cancer Research, shows that Δ9-tetrahydrocannabinol (THC), through activation of CB2 cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis

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Intratumor THC For Glioblastoma Multiforme

By | Brain Health, Cancer, Research Articles, THC

Intratumor THC For Glioblastoma Multiforme

Published in the British Journal of Cancer in 2006, these scientists reported ‘the first clinical study aimed at assessing cannabinoid antitumoral action, specifically a pilot phase I trial in which nine patients with recurrent glioblastoma multiforme were administered THC intratumoraly. The patients had previously failed standard therapy (surgery and radiotherapy) and had clear evidence of tumour progression’. Read More

Inhibition Of Human Tumour Prostate PC-3 Cell Growth

By | Cancer, Research Articles

Cannabis and Prostate Cancer | Prostate Cancer Treatments

Cannabis and Prostate cancer: There is considerable interest in the application of selective CB2 receptor agonists, which are devoid of typical marijuana-like psychoactive properties of CB1 agonists, for future cannabinoid-based anticancer therapies. This study, done in Spain and published in the British Journal of Cancer in 2009, has findings that point to the potential application of cannabinoid receptor type 2 ligands as anti-tumour agents in prostate cancer. Read More

Cannabidiol Inhibits Proliferation and Invasion in Glioma Cells

By | Brain Health, Cancer, CBD, Research Articles

Cannabidiol Inhibits Proliferation and Invasion in Glioma Cells | CBD Brain Cancer

This study out of Spain and published in October 2013, confirms the antiproliferative and antiinvasive effects of CBD in two different glioma cell lines. Interestingly, these effects can also be extended to glioma cells that are well known to be D9-THC-resistant. This data adds further insights into CBD antitumor action, showing its ability to influence multiple cellular targets in the two cell lines with partial overlap. Read More

Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro

By | Cancer, CBD, Research Articles

Cannabis for Leukemia | Research on Cannabis and Cancer

The concomitant administration of various non-psychoactive plant cannabinoids demonstrates synergistic anti-cancer activity in human leukemia cells, according to preclinical trial data published online in the October 2013 journal Anticancer Research. They explored the activity of six cannabinoids, used both alone and in combination in leukemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Read More