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Endocannabinoid Signaling in Autism

By | Autism, Endocannabinoid System, Research Articles

Endocannabinoid Signaling in AutismIn July 2015, Neurotherapeutics published an article about Autism spectrum disorder (ASD), presenting a modern view of the endocannabinoid (eCB) system, and alterations of its main components in human patients and animal models relevant to ASD. Our understanding of eCB signaling in autism is still in its infancy compared with other disorders of the central nervous system or of peripheral tissues, where eCB-based therapies have already reached preclinical and clinical phases. However, research in this field is rapidly evolving, and novel drugs able to hit specifically a distinct element of the eCB system are being developed at a surprising speed. Read More

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells

By | Breast Cancer, CBD, Research Articles

Cannabidiol Induces Programmed Cell Death in Breast Cancer CellsA study by researchers at Harvard Medical School was published in Molecular Cancer Therapeutics in 2011 characterizing the mechanism underlying the antitumoral properties of cannabidiol (CBD). This study showed that CBD induced both apoptosis and autophagy-induced death in breast cancer cells and inhibited the survival of both estrogen receptor-positive and estrogen receptor-negative breast cancer cell lines. These data enhance the desirability of CBD as an anticancer agent, because they suggest that CBD preferentially kills breast cancer cells, while minimizing damage to normal breast tissue.
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Cannabidiol Inhibits Human Glioma Cell Migration

By | Brain Health, Cancer, CBD, Research Articles

CaCannabidiol Inhibits Human Glioma Cell MigrationIn 2005, the British Journal of Pharmacology published a study evaluating the ability of cannabidiol (CBD) to impair the migration of tumor cells and thus act as a potential antitumoral compound. The results of the study reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. This antimigratory property, together with the known antiproliferative and apoptotic features of CBD, strengthen the evidence for its use as a potential antitumoral agent.
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Medical Marijuana Laws and Adolescent Marijuana Use in the USA from 1991 to 2014

By | Adolescent, History, Research Articles

Medical Marijuana Laws and Adolescent Marijuana Use in the USAIn the current June 2015 issue of Lancet, findings consistent with previous evidence suggest that passage of state medical marijuana laws does not increase adolescent use of marijuana. Whether access to a substance for medical purposes should be determined by legislation rather than biomedical research and regulatory review is debatable. However, concerns that increased adolescent marijuana use is an unintended effect of state medical marijuana laws seem unfounded. Read More

Alcohol and Cannabis

By | Research Articles

cannabis-alcoholPublished in the journal Clinical Chemistry, this research looked at blood and plasma levels of cannabinoids in participants vaporizing cannabis, with and without drinking alcohol. They found that the use of alcohol with cannabis significantly increased the amount of THC in the blood, thus explaining reported observations that cannabis plus alcohol causes Read More

Current Status and Future of Cannabis Research

By | History, Research Articles

Current Status and Future of Cannabis ResearchThis peer reviewed article from the April 2015 issue of Clinical Research explores the current status of cannabis research, including regulatory challenges & solutions, and discusses the future of the field. Although cannabis is primarily viewed by the public as a recreational drug or agent of abuse, its medical application spans recorded history. Read More