History of Cannabis

Fossil records suggest that close ancestors of the cannabis plant existed around 34 million years ago. Initially identified in central China, cannabis is thought to have been one of the first cultivated crops from which hemp was used to make rope, paper, and clothing.1 The cannabis plant was also used as food. Seeds from the plant were made into oil, and certain parts of the plant were used to make psychotropic drugs

Understanding feeling “high” and its role in medical cannabis patient outcomes

Our study uses data from the mobile health app, Releaf AppTM, through which 1,882 people tracked the effects of Cannabis flower on a multitude of health conditions during 16,480 medical cannabis self-administration sessions recorded between 6/5/2016 and 3/11/2021. Session-level reported information included plant phenotypes, modes of administration, potencies, baseline and post- administration symptom intensity levels, total dose used, and real-time side effect experiences.

A Retrospective Medical Record Review of Adults with Non-Cancer Diagnoses Prescribed Medicinal Cannabis

Research describing patients using medicinal cannabis and its effectiveness is lacking. We aimed to describe adults with non-cancer diagnoses who are prescribed medicinal cannabis via a retrospective medical record review and assess its effectiveness and safety. From 157 Australian records, most were female (63.7%; mean age 63.0 years). Most patients had neurological (58.0%) or musculoskeletal (24.8%) conditions. Medicinal cannabis was perceived beneficial by 53.5% of patients.

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort

Author: Eric P. Baron, Philippe Lucas, Joshua Eades & Olivia Hogue Published in The Journal of Headache and Pain May 2018 Abstract Background  Medicinal cannabis registries typically report pain as the…

A history of the Society of Cannabis Clinicians and its contributions and impact on the US medical cannabis movement

Dr. Kevin M.Takakuwa details the history of the SCC, which is the first and oldest U.S. medical organization promoting the use of medical cannabis.

Serious adverse effects of cannabidiol (CBD): a review of randomized controlled trials.

Authors: Rafael G. dos Santos, Francisco S. Guimarães, José Alexandre S. Crippa, et al
Expert Opinion on Drug Metabolism & Toxicology, 9 April 2020

Introduction: Recent trials using cannabidiol (CBD) have shown that most acute and prolonged adverse effects of CBD are mild to moderate, with rare serious adverse effects (SAEs). This review focused on analyzing SAEs of CBD and their possible relation to drug-drug interaction…

Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials.

Authors: Edward Chesney, Dominic Oliver, Alastair Green, Simina Sovi, Jack Wilson, Amir Englund, et al
Neuropsychopharmacology, 8 April 2020

Cannabidiol (CBD) is being investigated as a treatment for several medical disorders but there is uncertainty about its safety. We conducted the first systematic review and meta-analysis of the adverse effects of CBD across all medical indications. Double-blind randomized plac…

Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors

Authors: David B. Finlay, Kathleen J. Sircombe, Mhairi Nimick, Callum Jones, Michelle Glass
Frontiers in Pharmacology, 25 March 2020

The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the plant have provoked research i…

Labeling of Cannabidiol Products: A Public Health Perspective

Authors: Jamie Corroon, Douglas MacKay, William Dolphin
Cannabis and Cannabinoid Research, 6 March 2020

Introduction: Interest in the therapeutic use of cannabidiol (CBD) has reached a fever-pitch in recent months, as CBD-containing products appear everywhere from online retailers to grocery stores and gas stations. The widespread availability of hemp-derived CBD products is con…

Cannabis education needs assessment among Canadian physicians-in-training.

Canadian researchers found that the average training from physicians in training was 25% less than what they desired and that further training was paramount for them to engage in cannabis for therapeutic purposes (2020).

Medical students are unprepared to counsel patients about medical cannabis and want to learn more.

Authors: Abraham Benavides, Nicholas Gregorio, Puneet Gupta, Mikhail Kogan
Complementary Therapies in Medicine, January 2020

Introduction: Over-the-counter and prescribed medical cannabis products are used by patients for various conditions including psychiatric disorders, pain management, and other neurodegenerative conditions.1 Despite this growing public interest and increasing legal availability…

Indications and administration practices amongst medical cannabis healthcare providers: a cross-sectional survey.

A study published in BMC Family Practice sought to characterize the clinical practice characteristics of medical professionals who recommend cannabis.