Association Between Recent Cannabinoid Use and Acute Ischemic Stroke

Author: Carmela V. San Luis, Christa O’Hana S. Nobleza, Shashank Shekhar, Rebecca Sugg, Darren J. Villareal, Tapan Mehta, Shreyas Gangadhara Published in Frontiers in Psychology June 2020 Abstract Objectives Studies that have analyzed the association between cannabis use and acute ischemic stroke have provided conflicting results. In this study, we aim to determine the association of…

Cannabinoids and the expanded endocannabinoid system in neurological disorders.

Authors: Luigia Cristino, Tiziana Bisogno, Vincenzo Di Marzo
Nature Reviews Neurology, January 2020

Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated efforts to develop cannabinoid-based therapeutics. These efforts have been marked by disappointment, es…

The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review.

Authors: Mellar P. Davis, Bertrand Behm, Zankhana Mehta, Carlos Fernandez
American Journal of Hospice and Palliative Medicine, December 2019

Palmitoylethanolamide (PEA) is a nutraceutical endocannabinoid that was retrospectively discovered in egg yolks. Feeding poor children with known streptococcal infections prevented rheumatic fever. Subsequently, it was found to alter the course of influenza. Unfortunately, the…

The endocannabinoid system and stroke: A focused review.

Authors: Bradley Kolb, Hamidreza Saber, Hassan Fadel, Gary Rajah
Brain Circulation, January-March 2019

Stroke is an important cause of morbidity and mortality worldwide. Development of novel neuroprotectants is of paramount importance. This review seeks to summarize the recent evidence for the role of the endocannabinoid signaling system in stroke pathophysiology, as well as th…

Cannabis use predicts risks of heart failure and cerebrovascular accidents: results from the National Inpatient Sample.

Authors: Aditi Kalla, Parasuram Krishnamoorthy, Akshaya Gopalakrishnan, Vincent Figueredo
Journal of Cardiovascular Medicine, September 2018

BACKGROUND: Cannabis for medicinal and/or recreational purposes has been decriminalized in 28 states as of the 2016 election. In the remaining states, cannabis remains the most commonly used illicit drug. Cardiovascular effects of cannabis use are not well established due to a…

Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke.

Authors: Isabel Bravo-Ferrer, María I. Cuartero , Juan G. Zarruk, Jesús M. Pradillo, Olivia Hurtado, et al
Stroke, January 2017

BACKGROUND AND PURPOSE: Stroke is a leading cause of adult disability characterized by physical, cognitive, and emotional disturbances. Unfortunately, pharmacological options are scarce. The cannabinoid type-2 receptor (CB2R) is neuroprotective in acute experimental stroke by …