Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans.

Authors: Johannes Fuss, Laura Bindila, Klaus Wiedemann, Matthias K. Auer, Peer Briken, Sarah V. Biedermann
Journal of Sexual Medicine, November 2017

BACKGROUND: Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists o…

Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?

Authors: Renata Androvicova, Jiri Horacek, Tibor Stark, Filippo Drago, Vincenzo Micale
Pharmacological Research, January 2017

The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana’s psychoactive ingredient Δ9-tetrahydrocannabinol (Δ9-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis…

Circulating endocannabinoid concentrations and sexual arousal in women.

Authors: Carolin Klein, Matthew N. Hill, Sabrina C.H. Chang, Cecilia J. Hillard, Boris B. Gorzalka
Journal of Sexual Medicine, June 2012

INTRODUCTION: Several lines of evidence point to the potential role of the endocannabinoid system in female sexual functioning. These include results from studies describing the subjective effects of exogenous cannabinoids on sexual functioning in humans and the observable eff…