Cannabidiol for Viral Diseases: Hype or Hope?

Authors: Alex Mabou Tagne, Barbara Pacchetti, Mikael Sodergren, Marco Cosentino, and Franca Marino Published in Mary Ann Liebert, Inc Publishers June 2020 Abstract Background: The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that CBD could be…

Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.

Authors: Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat A. Panuganti, Shuling Ren, et al
Clinical Cancer Research, 13 January 2020

PURPOSE: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the interaction between cannab…

Marijuana use in hepatitis C infection does not affect liver biopsy histology or treatment outcomes.

Authors: Theresa Liu, Glen T Howell, Lucy Turner, Kimberley Corace, Gary Garber, Curtis Cooper
Canadian Journal of Gastroenterology & Hepatology, July-August 2014

BACKGROUND: Marijuana smoking is prevalent among hepatitis C virus-infected patients. The literature assessing the influence of marijuana on liver disease progression and hepatitis C virus antiviral treatment outcomes is conflicting. METHODS: The authors evaluated hepatitis C…

Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.

Authors: Cristina Maria Costantino, Achla Gupta, Alice W. Yewdall, Benjamin M. Dale, et al
PLoS One, 2012

Agents that activate cannabinoid receptor pathways have been tested as treatments for cachexia, nausea or neuropathic pain in HIV-1/AIDS patients. The cannabinoid receptors (CB(1)R and CB(2)R) and the HIV-1 co-receptors, CCR5 and CXCR4, all signal via Gαi-coupled pathways. We…

Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro.

Authors: Maria M. Medveczky, Tracy A. Sherwood, Thomas W. Klein, Herman Friedman, Peter G. Medveczky
BMC Medicinevolume, 15 September 2004

BACKGROUND: The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei i…