Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol.

Authors: Patrycja Bielawie, Ewa Harasim-Symbor, Adrian Chabowski
Frontiers in Endocrinology, 4 March 2020

Currently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide. It is well-known that the above states can lead to the development of type 2 diabetes, hypertension, and cardiovascular diseases. An excessive amount of tria…

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.

Authors: Dixon H. Xu, Benjamin D. Cullen, Meng Tang, Yujiang Fang
Current Pharmaceutical Biotechnology, December 2019

BACKGROUND: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the current treatment algorithm often fail to deliver adequate symptom relief. There has, however, been an increasing body of evidence for the use of ca…

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases.

Authors: Maura Argenziano, Chiara Tortora, Giulia Bellini, Alessandra Di Paola, Francesca Punzo, et al
International Journal of Molecular Sciences, 23 November 2019

Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. CB2, to a great extent, and CB1, to a lesser extent, are involved in regulating the im…

Therapeutic potential of cannabinoid receptor 2 in the treatment of diabetes mellitus and its complications.

Authors: Vivek S. Kumawat, Ginpreet Kaur
European Journal of Pharmacology, 5 November 2019

The biological effects of endocannabinoid system are mediated by two types of receptors, cannabinoid 1 (CB1) and cannabinoid 2 receptor (CB2). They play a pivotal role in the management of pain, inflammation, cancer, obesity and diabetes mellitus. CB2 receptor activity downreg…

Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome.

Authors: Shira Hirsch, Joseph Tam
Toxins, 15 May 2019

In this review, we discuss the role of the endocannabinoid (eCB) system in regulating energy and metabolic homeostasis. Endocannabinoids, via activating the cannabinoid type-1 receptor (CB1R), are commonly known as mediators of the thrifty phenotype hypothesis due to their act…

Role of Cannabinoid Receptor Type 1 in Insulin Resistance and Its Biological Implications.

Authors: Arulkumar Nagappan, Jooyeon Shin, Myeong Ho Jung
International Journal of Molecular Sciences, 29 April 2019

Endogenous cannabinoids (ECs) are lipid-signaling molecules that specifically bind to cannabinoid receptor types 1 and 2 (CB1R and CB2R) and are highly expressed in central and many peripheral tissues under pathological conditions. Activation of hepatic CB1R is associated with…

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy.

Authors: Mark S. Wallace, Thomas D. Marcotte, Anya Umlauf, Ben Gouaux, Joseph H. Atkinson
The Journal of Pain, July 2015

A randomized, double-blinded, placebo controlled crossover study was conducted in 16 patients with painful diabetic peripheral neuropathy to assess the short-term efficacy and tolerability of inhaled cannabis. In a crossover design, each participant was exposed to 4 single dos…

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults.

Authors: Elizabeth A. Penner, Hannah Buettner, Murray A. Mittleman
The American Journal of Medicine, July 2013

BACKGROUND: There are limited data regarding the relationship between cannabinoids and metabolic processes. Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana, suggestin…

Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III.

Authors: Tripathi B. Rajavashisth, Magda Shaheen, Keith C. Norris, Deyu Pan, et al
BMJ Open, 24 February 2012

OBJECTIVE: To determine the association between diabetes mellitus (DM) and marijuana use. DESIGN: Cross-sectional study. SETTING: Data from the National Health and Nutrition Examination Survey (NHANES III, 1988-1994) conducted by the National Center for Health Statistics of th…