The synergistic anticancer effect of CBD and DOX in osteosarcoma

Osteosarcoma is a malignant tumor that can present with pain in the bones, joints, and local masses. The incidence is highest in adolescents, and the most common sites are the distal femur, proximal tibia and proximal humerus metaphyseal. Doxorubicin is the first-line chemotherapeutic agent for the treatment of osteosarcoma, but it has many side effects. Cannabidiol is a non-psychoactive plant cannabinoid cannabinol (CBD) that has been shown to be effective against osteosarcoma; however, the molecular targets and mechanisms of CBD action in osteosarcoma remain unclear.

Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer’s Disease and Less Well-Known Diseases

Authors: Juan A. Paez, Nuria E. Campillo
Current Medicinal Chemistry, 25 February 2018

The discovery of cannabinoid receptors at the beginning of the 1990s, CB1 being cloned in 1990 and CB2 cloned in 1993, and the availability of selective and potent cannabimimetics could only be justified by the existence of endogenous ligands that are capable of binding to the…

A collaboration investigating endocannabinoid signalling in brain and bone.

Authors: Andreas Zimmer
Journal of Basic and Clinical Physiology and Pharmacology, 1 May 2016

Investigations into the cellular and molecular mechanisms underlying the psychoactive effects of cannabis preparations have led to the discovery of the endocannabinoid system. Interest in the central nervous system effects was initially the main focus of the research, but it s…

Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.

Authors: Alysia N. Lozano‐Ondoua, Katherine E. Hanlon, Ashley M. Symons‐Liguori, et al
Journal of Bone and Mineral Research, January 2013

Most commonly originating from breast malignancies, metastatic bone cancer causes bone destruction and severe pain. Although novel chemotherapeutic agents have increased life expectancy, patients are experiencing higher incidences of fracture, pain, and drug-induced side effec…