In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa

Authors: Ayat Zagzoog, Kawthar A. Mohamed, Hye Ji J. Kim, Eunhyun D. Kim, Connor S. Frank, Tallan Black, Pramodkumar D. Jadhav, Larry A. Holbrook & Robert B. Laprairie Published in Scientific Reports November 2020 Abstract The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), comparatively little…

Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Coronavirus Disease-2019

Authors: Prakash Nagarkatti, Kathryn Miranda and Mitzi Nagarkatti Published in Frontiers in Pharmacology November 2020 Abstract Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2. A significant proportion of COVID-19 patients develop Acute Respiratory Distress Syndrome (ARDS) resulting from hyperactivation of the immune system and…

Experience of Migraine, its Severity, and Perceived Efficacy of Treatments among Cannabis Users

A study from Complementary Therapies in Medicine in 2020 examines patterns of cannabis use and its associated relief among migraineurs.

A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety

Dylan Zylla, MD and colleagues give an overview of cannabis treatments for cancer patients. They provide guidance to clinicians on how to have informed discussions regarding their care.

Impact of Medical Cannabis on Patient-Reported Symptoms for Patients With Cancer Enrolled in Minnesota’s Medical Cannabis Program

Authors: Susan P Anderson, Dylan M Zylla, Deepa M McGriff, Tom J Arneson Published in Journal of Oncology Practice April 2019 Abstract Purpose: Minnesota’s medical cannabis program is unique, in that it routinely collects patient-reported scores on symptoms. This article focuses on changes in symptom severity reported by patients with cancer during their first 4 months…

Oncology Clinicians and the Minnesota Medical Cannabis Program: A Survey on Medical Cannabis Practice Patterns, Barriers to Enrollment, and Educational Needs

Authors: Dylan Zylla, Grant Steele , Justin Eklund, Jeanne Mettner, Tom Arneson Published in Cannabis and cannabinoid research October 2018 Abstract Background:Medical cannabis has been available in the State of Minnesota since July 2015 through the Minnesota Medical Cannabis Program (MMCP). Objectives: Our study aimed to delineate oncology providers’ views on medical cannabis, identify barriers…

Cannabis and Cancer Survey

Investigators from the Cancer Research Center would like to better understand the opinions of patients and/or their loved ones about the use of medical cannabis.

Cannabinoids in Urology. Which Benign Conditions Might They Be Appropriate to Treat: A Systematic Review

Authors: Brian Robert Peter Birch, Charlie Taylor Published in Urology November 2020 Abstract There is growing evidence suggesting cannabinoids may provide suitable alternatives to conventional treatments in an increasing number of clinical settings. This review evaluates how cannabinoids are used to treat certain benign urologicalpathologies and to clarify the clinical value of this data. This…

FURTHER EVIDENCE OF ANXIETY- AND DEPRESSION-LIKE BEHAVIOR FOR TOTAL GENETIC ABLATION OF CANNABINOID RECEPTOR TYPE 1

Authors: Delia Soriano, Alicia Brusco, Laura Caltana Published in Behavioural Brain Research November 2020 Abstract Cannabinoid receptor type 1 (CB1R) is the most abundant cannabinoid receptor in central nervous system. Clinical studies and animal models have shown that the attenuation of endocannabinoid system signaling correlates with the development of psychiatric disorders such as anxiety, depression…

Cannabis Medicines & the World Health Organization

A video update from Kenzi Riboulet-Zemouli and Michael Krawitz on the World Health Organization’s recommendations on cannabis scheduling and international cannabis law.

Cannabis Use May Reduce Healthcare Utilization and Improve Hospital Outcomes in Patients with Cirrhosis

Authors: Lindsay A. Sobotka, Khalid Mumtaz, Alice Hinton, Sean G. Kelly, Lanla F. Conteh, Anthony J. Michaels, A. James Hanje, Michael R. Wellnera Published in Annals of Hepatology November 2020 Abstract Introduction and Objectives:  Previous studies reveal conflicting data on the effect of cannabis use in patients with cirrhosis. This research evaluates the impact of…

Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression

Authors: Jianfeng Wang, Yunze Xu, Yun Zou, Liangsong Zhu, Baijun Dong, Jiwei Huang, Yonghui Chen, Wei Xue, Yiran Huang, Wen Kong & Jin Zhang Published in Tumor Biology October 2016 Abstract Renal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis. Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently…