Category

Opioids

Use of Prescription Pain Medications Among Medical Cannabis Patients

By | Opioids, Pain, Research Articles

Use of Prescription Pain Medications Among Medical Cannabis PatientsIn 2015, researchers at the University of Michigan published the first systematic comparison among medical cannabis users who use and do not use prescription pain medications (PPMs). PPM users and nonusers did not exhibit any difference in either lifetime or past-3-month use of other drugs, including cocaine, sedatives, street opioids, and amphetamines. PPM users rated the efficacy of cannabis higher than PPM for pain management and indicated a strong desire to reduce PPM usage. Longitudinal study designs are needed to better understand the trajectories of alcohol and other drug involvement over time among medical cannabis users. Read More

Cannabinoid–Opioid Interaction in Chronic Pain

By | Chronic Pain, Opioids, Research Articles

Cannabinoid Opioid Interaction in Chronic PainIn 2011, Nature Publishing Group released an article by researchers at the University of California, San Francisco, who undertook a study of twenty-one individuals with chronic pain to delineate the synergistic effects of cannabinoids and opioids. The study concluded that vaporized cannabis augments the analgesic effects of opioids without significantly altering plasma opioid levels. The combination may allow for opioid treatment at lower doses with fewer side effects. Read More

Cannabis and Pain Medication

By | Chronic Pain, Opioids, Pain, Research Articles

Cannabis and Pain MedicationManagement of chronic pain is one of the most common reasons given by individuals seeking medical cannabis. However, very little information exists about the concurrent use of cannabis and prescription pain medication (PPM). This study fills this gap in knowledge by systematically comparing medical cannabis users who use or do not use PPM, with an emphasis on Read More

Opioid Dependence And Cannabis

By | Addiction, Opioids, Research Articles

Opioid Dependence And Cannabis

This study published in the American Journal of Addiction in 2009, replicates a previously surprising finding that intermittent cannabis use is associated with improved retention in naltrexone treatment among opioid dependent patients, while both abstinence from cannabis and regular cannabis use during naltrexone treatment are associated with high dropout. Read More

Pain Measurements And Side Effect Profile Of The Novel Cannabinoid Ajulemic Acid

By | Chronic Pain, Endocannabinoid System, Inflammation, Neuropathy, Opioids, Pain, Research Articles

Cannabinoid AJA | Ajulemic Acid | Cannabis Pain Relief | Cannabis Anti-Inflammatory

In 2005, as published in the journal Neuropharmacology, researchers in Germany found pain relief in a synthetic cannabinoid called ajulemic acid. Synthetic modification of the THC metabolite THC-11-oic acid through replacement of the n-pentyl side chain with a dimethylheptyl group leads to the compound 1,1-dimethylheptyl-D8-THC-11-oic acid, named ajulemic acid (AJA) In preclinical studies AJA showed high analgesic potency comparable to morphine, as well as anti-allodynic and anti-inflammatory effects. AJA appears to have no detectable THC like psychoactive properties. Read More

Cannabis for Opioid Harm Reduction

By | Chronic Pain, Neuropathy, Opioids, Pain, Research Articles

Cannabis for Opioid Harm Reduction | Cannabis and Opiates

Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning. The author suggests that physicians who treat neuropathic pain with opioids should evaluate their patients for a trial of cannabis and prescribe it when appropriate prior to using opioids. This harm reduction strategy may reduce the morbidity and mortality rates associated with prescription pain medications. Read More