Posts

Dangerous plants in dermatology: Legal and controlled.

Authors: Deeptej Singh, Juliya Fisher, Devorah Shagalov, Aakaash Varma, Daniel M. Siegel
Clinics in Dermatology, May-June 2018

The plant and mushroom kingdoms have species used for intoxication, inebriation, or recreation. Some of these species are toxic. Given that many of these plants or substances are illegal and have histories of abuse, much of the research regarding therapeutic application is bas…

Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line.

Authors: Golnaz Vaseghi, Mohamad Javad Taki, Shaghayegh Haghjooy Javanmard
Iranian journal of basic medical sciences, October 2017

OBJECTIVES: Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardized…

The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.

Authors: E Pérez-Gómez, C Andradas, J M Flores, M Quintanilla, J M Paramio, M Guzmán, C Sánchez
Oncogene, 16 May 2013

G protein-coupled receptors (GPCRs) control crucial physiological processes and their dysfunction contributes to various human diseases, including cancer. The orphan GPCR GPR55 was identified and cloned more than a decade ago, but very little is known about its physio-patholog…