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Epigenetic control of skin differentiation genes by phytocannabinoids.

Authors: Mariangela Pucci, Cinzia Rapino, Andrea Di Francesco, Enrico Dainese, et al
British Journal of Pharmacology, October 2013

BACKGROUND AND PURPOSE: Endocannabinoid signalling has been shown to have a role in the control of epidermal physiology, whereby anandamide is able to regulate the expression of skin differentiation genes through DNA methylation. Here, we investigated the possible epigenetic r…

Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1.

Authors: Balázs I. Tóth, Nóra Dobrosi, Angéla Dajnoki, Gabriella Czifra, Attila Oláh, et al
Journal of Investigative Dermatology, May 2011

We have recently shown that lipid mediators of the emerging endocannabinoid system (ECS) are key players of growth control of the human pilosebaceous unit. In this study, we asked whether the prototypic endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) has a role in…

Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.

Authors: Sofia Magina, Carina Esteves-Pinto, Eduardo Moura, Maria Paula Serrão, et al
Archives of Dermatological Research, April 2011

Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between th…

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

Authors: Jonathan D. Wilkinson, Elizabeth M. Williamson
Journal of Dermatological Science, February 2007

BACKGROUND: Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and…