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Topical Δ9‐Tetrahydrocannabinol and Aqueous Dynamics in Glaucoma

Author: JOHN C. MERRITT M.D. DWIGHT D. PERRY M.D. DAVID N. RUSSELL M.D. BRENDA F. JONES M.D. Published in American College of Clinical Pharmacology  September 1981 Abstract Systemic Δ9‐tetrahydrocannabinol (THC), administered either by smoking marihuana or as synthetic THC in soft gelatin capsules, lowers ocular tension in various glaucomas, but at the expense of significant decreases…

Cannabis and glaucoma: A literature review

Author: Kathleen MacMillan MacMillan, Amanda Keddy, James Furlon Published in Dalhousie Medical Journal  2019 Abstract Introduction: Primary open-angle glaucoma (POAG) is characterized by the loss of retinal ganglion cells secondary to optic neuropathy; increased intraocular pressure (IOP) may or may not be present. Many treatment options focus on decreasing IOP measurements to attempt to prevent progression…

Diurnal and 24-h Intraocular Pressures in Glaucoma: Monitoring Strategies and Impact on Prognosis and Treatment

Author: Anastasios G. Konstas, Malik Y. Kahook, Makoto Araie, Andreas Katsanos, Luciano Quaranta, Luca Rossetti, Gábor Holló, Efstathios T. Detorakis, Francesco Oddone, Dimitrios G. Mikropoulos & Gordon N. Dutton Published in Springer Link  October 2008 Abstract The present review casts a critical eye on intraocular pressure (IOP) monitoring and its value in current and future glaucoma…

Experiences with Administration of Marihuana to Glaucoma Patients

Author: Robert S. HeplerRobert J. Petrus Published in Springer Link  1976 Abstract In 1971 Hepler and Frank reported reduction in intraocular pressure occurring after healthy young adults smoked marihuana. These initial observations led to additional studies designed to compare the pressure-reducing effects of placebo, smoked marihuana, and injected THC. Consistent, statistically-significant pressure reduction was observed in…

Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol

Author: Brenda K.Colasanti, Charles R. Craig, R. David Allara Published in Science Direct September 1984 Abstract Cannabinol or cannabigerol was administered to cats topically in doses of 250, 500 and 1000 μg as a single drop or chronically via osmotic minipumps (20 μg hr−1) over a period of 9 days. While cannabinol had a modest…

Finding of endocannabinoids in human eye tissues: Implications for glaucoma

Author: June Chen, Isabel Matias, Tim Dinh, Ta Lu, Sonia Venezia, Amelia Nieves, David F. Woodward, Vincenzo Di Marzo Published in Science Direct May 2005 Abstract Cannabinoid CB1 receptors are involved in ocular physiology and may regulate intraocular pressure (IOP). However, endocannabinoid levels in human ocular tissues of cornea, iris, ciliary body, retina, and choroid from…