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Endocannabinoids Modulate Human Epidermal Keratinocyte Proliferation and Survival via the Sequential Engagement of Cannabinoid Receptor-1 and Transient Receptor Potential Vanilloid-1

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We have recently shown that lipid mediators of the emerging endocannabinoid system (ECS) are key players of growth control of the human pilosebaceous unit. In this study, we asked whether the prototypic endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) has a role in growth and survival of epidermal keratinocytes (KCs).

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Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration

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Author: I. Matias, J.W. Wang, A. Schiano Moriello, A. Nieves, D.F. Woodward,V. Di Marzo Published in Science Direct December 2006 Abstract Cannabinoid receptors and the endocannabinoids (anandamide (N-arachidonoylethanolamine—AEA) and 2-arachidonoylglycerol (2-AG)),…

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Finding of endocannabinoids in human eye tissues: Implications for glaucoma

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Author: June Chen, Isabel Matias, Tim Dinh, Ta Lu, Sonia Venezia, Amelia Nieves, David F. Woodward, Vincenzo Di Marzo Published in Science Direct May 2005 Abstract Cannabinoid CB1 receptors are involved…

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Plasma anandamide concentrations are lower in children with autism spectrum disorder.

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Authors: Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, et al
Molecular Autism, 12 March 2018
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BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research ha…

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Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans.

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Authors: Johannes Fuss, Laura Bindila, Klaus Wiedemann, Matthias K. Auer, Peer Briken, Sarah V. Biedermann
Journal of Sexual Medicine, November 2017
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BACKGROUND: Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists o…

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Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study.

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Authors: A Neumeister, M D Normandin, R H Pietrzak, D Piomelli, M Q Zheng, A Gujarro-Anton, et al
Molecular Psychiatry, September 2013
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Endocannabinoids and their attending cannabinoid type 1 (CB1) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using posit…

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The molecular connections between the cannabinoid system and endometriosis.

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Authors: A.M. Sanchez, P. Vigano, A. Mugione, P. Panina-Bordignon, M. Candiani
Molecular Human Reproduction, December 2012
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The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid 1 (CB1) and 2 (CB2) receptors. Alterations of this system have been described in almost every category of disease. These changes can be protective or maladaptive…

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Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1.

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Authors: Balázs I. Tóth, Nóra Dobrosi, Angéla Dajnoki, Gabriella Czifra, Attila Oláh, et al
Journal of Investigative Dermatology, May 2011
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We have recently shown that lipid mediators of the emerging endocannabinoid system (ECS) are key players of growth control of the human pilosebaceous unit. In this study, we asked whether the prototypic endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) has a role in…

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Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.

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Authors: Sofia Magina, Carina Esteves-Pinto, Eduardo Moura, Maria Paula Serrão, et al
Archives of Dermatological Research, April 2011
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Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between th…

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Attenuation of allergic contact dermatitis through the endocannabinoid system.

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Authors: Meliha Karsak, Evelyn Gaffal, Rahul Date, Lihua Wang-Eckhardt, Jennifer Rehnelt, et al
Science, 8 June 2007
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Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors di…

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Fatty acid amide hydrolase deficiency limits early pregnancy events.

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Authors: Haibin Wang, Huirong Xie, Yong Guo, Hao Zhang, Toshifumi Takahashi, et al
Journal of Clinical Investigation, August 2006
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Synchronized preimplantation embryo development and passage through the oviduct into the uterus are prerequisites for implantation, dysregulation of which often leads to pregnancy failure in women. Cannabinoid/endocannabinoid signaling via cannabinoid receptor CB1 is known to…

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Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential.

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Authors: C. H. Ashton, P. B. Moore, P. Gallagher, A. H. Young
Journal of Psychopharmacology, May 2005
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Bipolar affective disorder is often poorly controlled by prescribed drugs. Cannabis use is common in patients with this disorder and anecdotal reports suggest that some patients take it to alleviate symptoms of both mania and depression. We undertook a literature review of can…

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