The Effect of Piperine on Oral Absorption of Cannabidiol following Acute vs. Chronic Administration.

Authors: Dvora Izgelov, Abraham J. Domb, Amnon Hoffman
European Journal of Pharmaceutical Sciences, 17 March 2020

The piperine is an alkaloid naturally found mostly in black pepper with a myriad of pharmacological attributes. The most far reaching indication of piperine is its use as an absorption enhancer, with supportive data regarding piperine’s ability to inhibit first pass effect mec…

Drug interactions with cannabinoids.

Authors: Tony Antoniou, Jack Bodkin, Joanne M.-W. Ho
CMAJ : Canadian Medical Association journal, 2 March 2020

Cannabinoid levels can be increased by other medications. Cannabinoids can affect levels of other drugs. Smoking marijuana can increase clearance of some drugs. Additive effects can occur with other drugs. There are potential “red flag” interactions.

Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug–Drug Interactions.

Authors: Joshua D. Brown
Journal of Clinical Medicine, 28 February 2020

Tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis. While the safety of THC and cannabis has been extrapolated from millennia of recreational use, medical marijuana programs have increased exposure among medically complex individuals with comorbid co…

Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use.

Authors: Joshua D. Brown, Almut G. Winterstein
Journal of Clinical Medicine, 8 July 2019

Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects and associated adverse drug events (ADEs) along with the potential for pharmacokinetic and pharm…