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The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases.

Authors: Maura Argenziano, Chiara Tortora, Giulia Bellini, Alessandra Di Paola, Francesca Punzo, et al
International Journal of Molecular Sciences, 23 November 2019

Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. CB2, to a great extent, and CB1, to a lesser extent, are involved in regulating the im…

Marijuana use during and after pregnancy and association of prenatal use on birth outcomes: A population-based study.

Authors: Jean Y. Ko, Van T. Tong, Jennifer M. Bombard, Donald K. Hayes, John Davy, et al
Drug and Alcohol Dependence, June 2018

BACKGROUND: We sought to describe the correlates of marijuana use during and after pregnancy, and to examine the independent relationship between prenatal marijuana use and infant outcomes. STUDY DESIGN: We used state-specific data from the Pregnancy Risk Assessment Monitoring…

Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis

Authors: J K L Gunn, C B Rosales, K E Center, A Nuñez, S J Gibson, C Christ, J E Ehiri
BMJ Open, 5 April 2016

Objective: To assess the effects of use of cannabis during pregnancy on maternal and fetal outcomes. Data sources: 7 electronic databases were searched from inception to 1 April 2014. Studies that investigated the effects of use of cannabis during pregnancy on maternal and fet…

Psychotic experiences are linked to cannabis use in adolescents in the community because of common underlying environmental risk factors.

Authors: Sania Shakoor, Helena M.S. Zavos, Philip McGuire, Alastair G. Cardno, et al
Psychiatry Research, 30 June 2015

Cannabis users are more likely to have psychotic experiences (PEs). The degree to which these associations are driven by genetic or environmental influences in adolescence is unknown. This study estimated the genetic and environmental contributions to the relationship between…

The impact of marijuana policies on youth: clinical, research, and legal update.

Authors: COMMITTEE ON SUBSTANCE ABUSE, COMMITTEE ON ADOLESCENCE
Pediatrics, March 2015

This policy statement is an update of the American Academy of Pediatrics policy statement “Legalization of Marijuana: Potential Impact on Youth,” published in 2004. Pediatricians have special expertise in the care of children and adolescents and may be called on to advise legi…

Prenatal cannabis exposure and infant outcomes: overview of studies.

Authors: A.C. Huizink
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 3 July 2014

Accumulating evidence from both human and preclinical studies indicates maternal substance use during pregnancy can affect fetal development, birth weight and infant outcomes. Thus, the prenatal period can be regarded as an important and potentially sensitive period of develop…

School achievement in 14-year-old youths prenatally exposed to marijuana.

Authors: Lidush Goldschmidt, Gale A. Richardson, Jennifer A. Willford, Stevan G. Severtson, Nancy L. Day
Neurotoxicology and Teratology, January-February 2012

The relation between prenatal marijuana exposure (PME) and school achievement was evaluated in a sample of 524 14-year-olds. Women were recruited during pregnancy and assessed, along with their offspring, at multiple phases from infancy to early adulthood. The sample represent…

The endocannabinoid-CB(1) receptor system in pre- and postnatal life.

Authors: Ester Fride
European Journal of Pharmacology, October 2004

Recent research suggests that the endogenous cannabinoids (“endocannabinoids”) and their cannabinoid receptors have a major influence during pre- and postnatal development. First, high levels of the endocannaboid anandamide and cannabinoid receptors are present in the preimpla…

Prenatal marijuana and alcohol exposure and academic achievement at age 10.

Authors: Lidush Goldschmidt, Gale A Richardson, Marie D Cornelius, Nancy L Day
Neurotoxicology and Teratology, July-August 2004

The effects of prenatal marijuana and alcohol exposure on school achievement at 10 years of age were examined. Women were interviewed about their substance use at the end of each trimester of pregnancy, at 8 and 18 months, and at 3, 6, 10, 14, and 16 years. The women were of l…

The endocannabinoid-CB receptor system: Importance for development and in pediatric disease.

Authors: Ester Fride
Neuro endocrinology letters, February-April 2004

Endogenous cannabinoids (endocannabinoids) and their cannabinoid CB1 and CB2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism. Although most of these data are collected from animal studies, a role for cannab…

Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study.

Authors: Melanie C. Dreher, Kevin Nugent, Rebekah Hudgins
Pediatrics, February 1994

OBJECTIVE: To identify neurobehavioral effects of prenatal marijuana exposure on neonates in rural Jamaica. DESIGN: Ethnographic field studies and standardized neuro-behavior assessments during the neonatal period. SETTING: Rural Jamaica in heavy-marijuana-using population. PA…

Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy.

Authors: Jill S. Hayes, R Lampart, Melanie C Dreher, Lisa Morgan
The West Indian medical journal, September 1991

This research provides data on the development of 59 Jamaican children, from birth to age 5 years, whose mothers used marijuana during pregnancy. Approximately one-half of the sample used marijuana during pregnancy and were matched with non-users according to age, parity, and…