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Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.

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Authors: Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat A. Panuganti, Shuling Ren, et al
Clinical Cancer Research, 13 January 2020
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PURPOSE: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the interaction between cannab…

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The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.

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Authors: E Pérez-Gómez, C Andradas, J M Flores, M Quintanilla, J M Paramio, M Guzmán, C Sánchez
Oncogene, 16 May 2013
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G protein-coupled receptors (GPCRs) control crucial physiological processes and their dysfunction contributes to various human diseases, including cancer. The orphan GPCR GPR55 was identified and cloned more than a decade ago, but very little is known about its physio-patholog…

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Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study.

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Authors: Mia Hashibe, Hal Morgenstern, Yan Cui, Donald P. Tashkin, Zuo-Feng Zhang, et al
Cancer Epidemiology Biomarkers & Prevention, October 2008
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BACKGROUND: Despite several lines of evidence suggesting the biological plausibility of marijuana being carcinogenic, epidemiologic findings are inconsistent. We conducted a population-based case-control study of the association between marijuana use and the risk of lung and u…

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