Parkinson’s disease (PD) is a serious neurodegenerative condition impacting many individuals worldwide. There is a need for new non-invasive treatments of PD. Cannabinoids in the form of cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) may offer utility as treatment, and our objective was hence to conduct a systematic review regarding the clinical evidence for the efficacy and safety of cannabinoids in treating PD.
Previous research suggests an increase in schizophrenia population attributable risk fraction (PARF) for cannabis use disorder (CUD). However, sex and age variations in CUD and schizophrenia suggest the importance of examining differences in PARFs in sex and age subgroups. We conducted a nationwide Danish register-based cohort study including all individuals aged 16–49 at some point during 1972–2021. CUD and schizophrenia status was obtained from the registers. Hazard ratios (HR), incidence risk ratios (IRR), and PARFs were estimated. Joinpoint analyses were applied to sex-specific PARFs.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-05-21 18:02:182023-05-21 18:02:18Association between cannabis use disorder and schizophrenia stronger in young males than in females
Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to explore associations of acute and sustained use of legal market edible cannabis products on pain, cognition, and quality of life in a group of cancer patients. In this observational study, cancer patients completed a baseline appointment, a two-week ad libitum cannabis use period, and an acute administration appointment that included assessments before cannabis use, one-hour post-use, and two-hour post-use. Participants completed self-report questionnaires related to the primary outcomes and the Stroop task as a measure of objective cognitive function.
Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to explore associations of acute and sustained use of legal market edible cannabis products on pain, cognition, and quality of life in a group of cancer patients. In this observational study, cancer patients completed a baseline appointment, a two-week ad libitum cannabis use period, and an acute administration appointment that included assessments before cannabis use, one-hour post-use, and two-hour post-use. Participants completed self-report questionnaires related to the primary outcomes and the Stroop task as a measure of objective cognitive function.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-05-05 18:12:522023-05-05 18:12:52Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
Cannabis is the most used illicit drug in the world. Global trends of decriminalization and legali- zation of cannabis lead to various forms of cannabis use and bring great concerns over adverse events, partic- ularly in the cardiovascular (CV) system. To date, the association between cannabis and adverse CV events is still controversial. We aim to conduct a systematic review and meta-analysis to assess the adverse CV events from cannabis use.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-04-29 15:39:592023-04-29 15:39:59Cannabis and adverse cardiovascular events: A systematic review and meta-analysis of observational studies
Tinnitus has a significant impact on quality of life and causes considerable psychological distress. Cannabis is known to modulate neuron hyperexcitability, provide protection against auditory damage, and has been used for treatment for many diseases which have physiological similarities with tinnitus. The objective of this study was to survey patients presenting with tinnitus regarding their perspectives and usage patterns of cannabis. Patients with a primary presenting complaint of tinnitus in a tertiary neuro-otology clinic completed a 18-item questionnaire assessing perception, attitudes, and cannabis usage patterns.
There are several well-known treatments for Restless Legs Syndrome (RLS), including dopamine agonists (pramipexole, ropinirole, rotigotine), anticonvulsants (gabapentin and its analogs, pregabalin), oral or intravenous iron, opioids and benzodiazepines. However, in clinical practice, treatment is sometimes limited due to incomplete response or side effects and it is necessary to be aware of other treatment options for RLS, which is the purpose of this review. We performed a narrative review detailing all of the lesser known pharmacological treatment literature on RLS. The review purposefully excludes well-established, well-known treatments for RLS which are widely accepted as treatments for RLS in evidence-based reviews. We also have emphasized the pathogenetic implications for RLS of the successful use of these lesser known agents.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-04-29 04:46:382023-04-29 04:46:38A Narrative Review of the Lesser Known Medications for Treatment of Restless Legs Syndrome and Pathogenetic Implications for Their Use
The cannabis plant exerts its pharmaceutical activity primarily by the binding of cannabinoids to two G protein-coupled cannabinoid receptors, CB1 and CB2. The role that cannabis terpenes play in this activation has been considered and debated repeatedly, based on only limited experimental results. In the current study we used a controlled in-vitro heterologous expression system to quantify the activation of CB1 receptors by sixteen cannabis terpenes individually, by tetrahydrocannabinol (THC) alone and by THC-terpenes mixtures. The results demonstrate that all terpenes, when tested individually, activate CB1 receptors, at about 10-50% of the activation by THC alone.
The success of smoking cessation programs is inarguable and has saved thousands of lives by decreasing the incidence of deadly malignancies, including head and neck cancer. Meanwhile, we are witnessing an increasing incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC), especially in a population of older Caucasian males. Approval and use of immune checkpoint inhibitors (ICI), such as pembrolizumab, have resulted in improved outcomes in patients with HPV-induced OPSCC. It is successfully used in the treatment of recurrent and metastatic disease with meaningful improvements in overall survival. However, concurrent chemoradiotherapy (CCRT) remains the conventional first-line treatment of locally advanced disease in eligible patients and is associated with substantial morbidity.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-04-22 06:29:312023-04-22 06:29:31Locally advanced HPV-positive oropharyngeal cancer cured with single agent pembrolizumab in a patient using cannabis: a case report
Tinnitus has a significant impact on quality of life and causes considerable psychological distress. Cannabis is known to modulate neuron hyperexcitability, provide protection against auditory damage, and has been used for treatment for many diseases which have physiological similarities with tinnitus. The objective of this study was to survey patients presenting with tinnitus regarding their perspectives and usage patterns of cannabis. Patients with a primary presenting complaint of tinnitus in a tertiary neuro-otology clinic completed a 18-item questionnaire assessing perception, attitudes, and cannabis usage patterns.
Myofascial tenderness is present in most chronic pelvic pain conditions and causes significant distress to patients. Treatment is challenging and often not curative. Cannabis is often used for self-management of chronic pelvic pain. However, we do not know which concentrations and routes of administration are most acceptable to users. We aimed to investigate patterns and willingness of cannabis product use among both habitual users and non-users with myofascial pelvic pain (MPP), to inform therapeutic development.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-04-16 10:35:302023-04-16 10:35:30Cannabis use preferences in women with myofascial pelvic pain: A cross-sectional study
Inflammatory bowel diseases (IBDs) are chronic conditions of unknown cause or cure. Treatment seeks to reduce symptoms and induce and maintain remission. Many patients have turned to alternatives, such as cannabis, to alleviate living with IBD. This study reports the demographics, prevalence, and perception on cannabis use of patients attending an IBD clinic. Patients agreed to participate and completed an anonymous survey during their visit or online. Descriptive analysis, Fisher’s exact test, and Wilcoxon-Mann-Whitney rank-sum test were used. One hundred and sixty- two adults (85 males, 77 with CD) completed the survey. Sixty (37%) reported use of cannabis, of which 38 (63%) used it to relieve their IBD. A value of 77% reported low to moderate knowledge about cannabis, and 15% reported little to no knowledge. Among cannabis users, 48% had discussed use with their physician, but 88% said they would feel comfortable discussing medical cannabis for IBD. Most saw improvement of their symptoms (85.7%). A considerable number of patients with IBD use medical cannabis for their disease, unknown to their physician. The study reinforces the importance that physicians understand the role of cannabis in the treatment of IBD in order to appropriately counsel patients.
https://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.png00Michelle Smithhttps://www.cannabisclinicians.org/wp-content/uploads/2025/09/Main-logo-white.pngMichelle Smith2023-04-02 06:16:412023-04-02 06:16:41A Survey of Cannabis Use among Patients with Inflammatory Bowel Disease (IBD)
