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Cannabinoid Receptor Modulators

Endocannabinoid system in neurodegenerative disorders.

By | Neurodegenerative Diseases

Authors: Balapal S. Basavarajappa, Madhu Shivakumar, Vikram Joshi, Shivakumar Subbanna
Journal of Neurochemistry, September 2017

Most neurodegenerative disorders (NDDs) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression of these NDDs are not well-defined. Several mechanisms have been proposed to contribute to the develo…

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Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.

By | Skin Diseases

Authors: Sofia Magina, Carina Esteves-Pinto, Eduardo Moura, Maria Paula Serrão, et al
Archives of Dermatological Research, April 2011

Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between th…

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Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis.

By | Colitis, Digestive System Diseases

Authors: Francesca Borrelli, Gabriella Aviello, Barbara Romano, Pierangelo Orlando, et al
Journal of Molecular Medicine, November 2009

Inflammatory bowel disease affects millions of individuals; nevertheless, pharmacological treatment is disappointingly unsatisfactory. Cannabidiol, a safe and non-psychotropic ingredient of marijuana, exerts pharmacological effects (e.g., antioxidant) and mechanisms (e.g., inh…

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The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

By | Skin Diseases

Authors: Tamás Bíró, Balázs I. Tóth, György Haskó, Ralf Paus, Pál Pacher
Trends in Pharmacological Sciences, August 2009

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulat…

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The emerging role of the endocannabinoid system in cardiovascular disease.

By | Cardiovascular Diseases, Nutritional & Metabolic Diseases

Authors: Pál Pacher, Sabine Steffens
Seminars in Immunopathology, June 2009

Endocannabinoids are endogenous bioactive lipid mediators present both in the brain and various peripheral tissues, which exert their biological effects via interaction with specific G-protein-coupled cannabinoid receptors, the CB(1) and CB(2). Pathological overactivation of t…

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Attenuation of allergic contact dermatitis through the endocannabinoid system.

By | Skin Diseases

Authors: Meliha Karsak, Evelyn Gaffal, Rahul Date, Lihua Wang-Eckhardt, Jennifer Rehnelt, et al
Science, 8 June 2007

Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors di…

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Cannabis, cannabinoids and reproduction.

By | Pregnancy, Reproduction

Authors: Boram Park, John M. McPartland, Michelle Glass
Prostaglandins, Leukotrienes and Essential Fatty Acids, February 2004

In most countries Cannabis is the most widely used illegal drug. Its use during pregnancy in developed nations is estimated to be approximately 10%. Recent evidence suggests that the endogenous cannabinoid system, now consisting of two receptors and multiple endocannabinoid li…

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