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Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study.

Authors: Carmela Valastro, Debora Campanile, Mariarosaria Marinaro, Delia Franchini, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marzo, Antonio Di Bello
BMC Veterinary Research, 6 November 2017

BACKGROUND: Cannabis-based drugs have been shown to be effective in inflammatory diseases. A number of endocannabinoids including N- arachidonoylethanolamide (anandamide, AEA) and 2-arachidonyl glycerol (2-AG) with activity at the cannabinoid receptors (CBR) CBR1 and CBR2, hav…

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.

Authors: Alexandre Rafael de Mello Schier, Natalia Pinho de Oliveira Ribeiro, et al
Brazilian Journal of Psychiatry, June 2012

OBJECTIVES: To review and describe studies of the non-psychotomimetic constituent of Cannabis sativa, cannabidiol (CBD), as an anxiolytic drug and discuss its possible mechanisms of action. METHOD:
The articles selected for the review were identified through searches in Englis…

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.

Authors: A.W. Zuardi, J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira, F.S. Guimarães
Brazilian journal of medical and biological research, April 2006

A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent whi…

Antitussive activity of some naturally occurring cannabinoids in anesthetized cats.

Authors: Robert Gordon, Robert J.Gordon, R.Duane Sofia
European Journal of Pharmacology, February 1976

Experimental cough was elicited in pentobarbital-anesthetized cats by either electrical stimulation of the superior laryngeal nerve or by mechanical stimulation of the tracheal mucosa. Intravenous administration of delta9-tetrahydrocannabinol (THC) effectively reduced the ampl…

Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system.

Authors: Jessica Freundt-Revilla, Kristel Kegler, Wolfgang Baumgärtner, Andrea Tipold
PLoS One, 10 July 2017

The endocannabinoid system is a regulatory pathway consisting of two main types of cannabinoid receptors (CB1 and CB2) and their endogenous ligands, the endocannabinoids. The CB1 receptor is highly expressed in the central and peripheral nervous systems (PNS) in mammalians and…

Cannabis use during pregnancy: Pharmacokinetics and effects on child development.

Authors: Kimberly S.Grant, Rebekah Petroff, Nina Isoherranen, Nephi Stella, Thomas M. Burbacher
Pharmacology & Therapeutics, February 2018

The broad-based legalization of cannabis use has created a strong need to understand its impact on human health and behavior. The risks that may be associated with cannabis use, particularly for sensitive subgroups such as pregnant women, are difficult to define because of a p…

Cardiovascular and respiratory effects of cannabis in cat and rat.

Authors: J. D. P. Graham, D. M. F. Li
British Journal of Pharmacology, September 1973

1. In anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), Delta(1)-tetrahydrocannabinol (THC) (0.5 mg/kg) and Delta(6)-THC (0.5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate.2. Neither cannabinol (1 mg/kg, i.v…

Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease.

Authors: Jessica Margaret Sido, Prakash S. Nagarkatti, Mitzi Nagarkatti
International Reviews of Immunology, 2015

The impact of the endogenous cannabinoids (AEA, 2-AG, PEA, and virodamine) on the immune cell expressed cannabinoid receptors (CB1, CB2, TRPV-1, and GPR55) and consequent regulation of immune function is an exciting area of research with potential implications in the preventio…

Fatty acid amide hydrolase deficiency limits early pregnancy events.

Authors: Haibin Wang, Huirong Xie, Yong Guo, Hao Zhang, Toshifumi Takahashi, et al
Journal of Clinical Investigation, August 2006

Synchronized preimplantation embryo development and passage through the oviduct into the uterus are prerequisites for implantation, dysregulation of which often leads to pregnancy failure in women. Cannabinoid/endocannabinoid signaling via cannabinoid receptor CB1 is known to…

Marijuana intoxication in a cat.

Authors: Agnieszka Janeczek, Marcin Zawadzki, Pawel Szpot, Artur Niedzwiedz
Acta Veterinaria Scandinavica, 11 July 2018

BACKGROUND: Cannabis from hemp (Cannabis sativa and C. indica) is one of the most common illegal drugs used by drug abusers. Indian cannabis contains around 70 alkaloids, and delta-9-tetrahydrocannabinol (delta-9-THC) is the most psychoactive substance. Animal intoxications oc…

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function.

Authors: Guy A. Cabral, Thomas J. Rogers, Aron H. Lichtman
Journal of Neuroimmune Pharmacology, June 2015

Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in cannabis ∆(9)-tetrahydrocannabinol (THC) produces the majority of its pharmacological effects through two cannabinoid recep…

Cannabinoid exposure in adolescent female rats induces transgenerational effects on morphine conditioned place preference in male offspring.

Authors: John J Byrnes, Nicole L Johnson, Marian E Schenk, Elizabeth M Byrnes
Journal of Psychopharmacology, October 2012

In the United States, marijuana is one of the drugs most abused by adolescents, with females representing a growing number of users. In previous studies, treatment of adolescent female rats with morphine significantly altered brain reward systems in future offspring. As both c…