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The dose-dependent analgesic effects, abuse liability, safety and tolerability of oral cannabidiol in healthy humans

Preclinical studies demonstrate that cannabidiol (CBD) elicits an antinociceptive response in animal models of neuropathic pain; in humans, limited data are available to support such analgesic effects. Few studies have examined CBD’s analgesic effects when administered without other compounds, and little is known regarding dose-dependent effects in non-cannabis users.