About
A Puff Before a Pour: Dose-Dependent Effects of Cannabis on Drinking
Event Description:
This month’s journal club will examine a landmark randomized controlled crossover trial exploring how smoked cannabis affects alcohol craving and consumption under controlled laboratory conditions. With the rise of THC beverages, “Cali sober” trends, and increasing co-use of cannabis and alcohol, this study provides some of the strongest causal evidence to date on whether THC increases or decreases drinking. We will review the study’s design, outcomes, and implications for clinical practice, harm-reduction counseling, and public health messaging.
Key takeaway: Smoking cannabis with THC (3.1% and 7.2%) significantly reduced alcohol consumption by 19–27% compared to placebo, with nuanced effects on craving and urge.
Featured Article:
Metrik J, Aston ER, Gunn RL, Swift R, MacKillop J, Kahler CW.
Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial. American Journal of Psychiatry. 2025; XX:1–9.
DOI: TBA.
Speakers:
Phil Molloy, MD – Clinical education expert
Teresa Simon, MPH – Public health epidemiologist
Len Kamen, MD – Clinical pain specialist
Jahan Marcu, PhD – Cannabis researcher