Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Authors: Margherita Luongo, Oliviero Marinelli, Laura Zeppa, Cristina Aguzzi, Maria Beatrice Morelli, Consuelo Amantini, Andrea Frassineti, Marianne di Costanzo, Alessandro Fanelli, Giorgio Santoni, Massimo Nabissi Published in Cancers September 2020 Abstract Pancreatic cancer (PC) is related to lifestyle risks, chronic inflammation, and germline mutations in BRCA1/2, ATM, MLH1, TP53, or CDKN2A. Surgical resection and adjuvant…

Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease

Authors: Adeyinka C Adejumo, Tokunbo O Ajayi, Oluwole M Adegbala, Kelechi L Adejumo, Samson Alliu, Akintunde M Akinjero, Nnaemeka E Onyeakusi, Ogooluwa Ojelabi, Terence N Bukong Published in Liver International January 2018 Abstract Background: Abusive alcohol use has well-established health risks including causing liver disease (ALD) characterized by alcoholic steatosis (AS), steatohepatitis (AH), fibrosis, cirrhosis…

Medical cannabis and cognitive performance in middle to old adults treated for chronic pain

Authors: Sharon R Sznitman, Simon Vulfsons, David Meiri, Galit Weinstein Published in Drug and Alcohol Review September 2020 Abstract Introduction and aims: Cannabis exposure is becoming more common in older age but little is known about how it is associated with brain health in this population. This study assesses the relationship between long-term medical cannabis…

Cannabis: An Emerging Treatment for Common Symptoms in Older Adults

Authors: Kevin H Yang, Christopher N Kaufmann, Reva Nafsu, Ella T Lifset, Khai Nguyen, Michelle Sexton, Benjamin H Han, Arum Kim, Alison A Moore Published in Journal of the American Geriatrics Society October 2020 Abstract Background/objectives: Use of cannabis is increasing in a variety of populations in the United States; however, few investigations about how…

Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation

Authors: Ester Pagano, Fabio A. Iannotti, Fabiana Piscitelli, Barbara Romano, Giuseppe Lucariello, Tommaso Venneri, Vincenzo Di Marzo, Angelo A. Izzo, Francesca Borrelli Published in Phytotherapy Research September 2020 Abstract Summary Fish oil (FO) and phytocannabinoids have received considerable attention for their intestinal anti‐inflammatory effects. We investigated whether the combination of FO with cannabigerol (CBG) and…

Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol

Authors: Maximus Berger, Emily Li, Günter Paul Amminger Published in BMJ Case Reports CP 2020 Abstract Anxiety disorders in young people are frequently comorbid with other mental disorders and respond unsatisfactorily to first-line treatment in many cases. Here, we report the case of a 20-year-old man with severe social anxiety disorder, major depressive disorder, insomnia…

Biological Activity of Cannabis sativa L. Extracts Critically Depends on Solvent Polarity and Decarboxylation

SCC Member Gretchen E. Maurer, DO, MS and colleagues examine the current research potential for cannabis in sports medicine.

Medical Cannabis Treatment for Chronic Pain: Outcomes and Prediction of Response

Authors: Joshua Aviram, Dorit Pud, Tamar Gershoni, Bareket Schiff‐Keren, Miriam Ogintz, Simon Vulfsons, Tamar Yashar, Adahan Haim‐Moshe, Silviu Brill, Howard Amital, Itay Goor‐Aryeh, Dror Robinson, Leslie Green, Refael Segal, Yacov Fogelman, Oren Tsvieli, Ben Yellin, Yelena Vysotski, Ofir Morag, Vadim Tashlykov, Roee Sheinfeld, Ruth Goor, David Meiri, Elon Eisenberg Published in European Journal of Pain…

Compassion Fatigue: Helping the Helper

Matt Cascio, RN discusses compassion fatigue and how this can impact those in the healthcare sector.

Preliminary Assessment of Medical Cannabis Consumption by Cancer Survivors

This study indicates that cancer survivors may indeed consume cannabis for symptom relief, and not merely for recreational purposes. More research is needed to study the adequate role that cannabis may have for treating symptoms associated with cancer survivorship.

Add-on cannabidiol significantly decreases seizures in 3 patients with SYNGAP1 developmental and epileptic encephalopathy

Authors: Mathieu Kuchenbuch, Gianluca D’Onofrio, Nicole Chemaly, Giulia Barcia, Théo Teng, Rima Nabbout Published in Epilepsia Open July 2020 Abstract Mutations in SYNGAP1 are associated with developmental delay, epilepsy, and autism spectrum disorder (ASD). Epilepsy is often drug-resistant in this syndrome with frequent drop attacks. In a prospective study of add-on cannabidiol (CBD), we identified…

Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production

Authors: William Becker, Haider Rasheed Alrafa,Kiesha Wilson, Kathryn Miranda, Courtney Culpepper, Ioulia Chatzistamou, Guoshuai Cai, Mitzi Nagarkatti, Prakash S. Nagarkatti Published in Iscience August 2020 Abstract Summary Intestinal disequilibrium leads to inflammatory bowel disease (IBD), and chronic inflammation predisposes to oncogenesis. Antigen-presenting dendritic cells (DCs) and macrophages can tip the equilibrium toward tolerance or pathology….