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Skin Diseases

Self-initiated use of topical cannabidiol oil for epidermolysis bullosa.

By | Pain, Skin Diseases

Authors: Malcolm P. Chelliah, Zachary Zinn, Phoung Khuu, Joyce M. C. Teng
Pediatric Dermatology, July 2018

Epidermolysis bullosa is a rare blistering skin disorder that is challenging to manage because skin fragility and repeated wound healing cause itching, pain, limited mobility, and recurrent infections. Cannabidiol, an active cannabinoid found in cannabis, is postulated to have…

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Dangerous plants in dermatology: Legal and controlled.

By | Cancer, Inflammation, Skin Cancer, Skin Diseases

Authors: Deeptej Singh, Juliya Fisher, Devorah Shagalov, Aakaash Varma, Daniel M. Siegel
Clinics in Dermatology, May-June 2018

The plant and mushroom kingdoms have species used for intoxication, inebriation, or recreation. Some of these species are toxic. Given that many of these plants or substances are illegal and have histories of abuse, much of the research regarding therapeutic application is bas…

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Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment.

By | Skin Diseases

Authors: Attila Oláh, Arnold Markovics, Judit Szabó‐Papp, Pálma Tímea Szabó, Colin Stott, et al
Experimental Dermatology, September 2016

Acne is a common skin disease characterized by elevated sebum production and inflammation of the sebaceous glands. We have previously shown that a non-psychotropic phytocannabinoid ((-)-cannabidiol [CBD]) exerted complex anti-acne effects by normalizing ‘pro-acne agents’-induc…

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Epigenetic control of skin differentiation genes by phytocannabinoids.

By | Genetics, Skin Diseases

Authors: Mariangela Pucci, Cinzia Rapino, Andrea Di Francesco, Enrico Dainese, et al
British Journal of Pharmacology, October 2013

BACKGROUND AND PURPOSE: Endocannabinoid signalling has been shown to have a role in the control of epidermal physiology, whereby anandamide is able to regulate the expression of skin differentiation genes through DNA methylation. Here, we investigated the possible epigenetic r…

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Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis.

By | Skin Diseases, Veterinary Medicine

Authors: Luca Campora, Vincenzo Miragliotta, Emanuele Ricci, Luigia Cristino, Vincenzo Di Marzo, et al
American Journal of Veterinary Research, July 2012

OBJECTIVE: To determine the distribution of cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2) in skin (including hair follicles and sweat and sebaceous glands) of clinically normal dogs and dogs with atopic dermatitis (AD) and to compare results with thos…

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Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1.

By | Skin Diseases

Authors: Balázs I. Tóth, Nóra Dobrosi, Angéla Dajnoki, Gabriella Czifra, Attila Oláh, et al
Journal of Investigative Dermatology, May 2011

We have recently shown that lipid mediators of the emerging endocannabinoid system (ECS) are key players of growth control of the human pilosebaceous unit. In this study, we asked whether the prototypic endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) has a role in…

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Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.

By | Skin Diseases

Authors: Sofia Magina, Carina Esteves-Pinto, Eduardo Moura, Maria Paula Serrão, et al
Archives of Dermatological Research, April 2011

Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between th…

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The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

By | Skin Diseases

Authors: Tamás Bíró, Balázs I. Tóth, György Haskó, Ralf Paus, Pál Pacher
Trends in Pharmacological Sciences, August 2009

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulat…

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Attenuation of allergic contact dermatitis through the endocannabinoid system.

By | Skin Diseases

Authors: Meliha Karsak, Evelyn Gaffal, Rahul Date, Lihua Wang-Eckhardt, Jennifer Rehnelt, et al
Science, 8 June 2007

Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors di…

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Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

By | Skin Diseases

Authors: Jonathan D. Wilkinson, Elizabeth M. Williamson
Journal of Dermatological Science, February 2007

BACKGROUND: Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and…

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