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The dual neuroprotective-neurotoxic profile of cannabinoid drugs.

Authors: Yosef Sarne, Fadi Asaf, Miriam Fishbein, Mikhal Gafni, Ora Keren
British Journal of Pharmacology, August 2011

Extensive in vitro and in vivo studies have shown that cannabinoid drugs have neuroprotective properties and suggested that the endocannabinoid system may be involved in endogenous neuroprotective mechanisms. On the other hand, neurotoxic effects of cannabinoids in vitro and i…

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.

Authors: Antonio Waldo Zuardi
Brazilian Journal of Psychiatry, September 2008

OBJECTIVE: The aim of this review is to describe the historical development of research on cannabidiol. METHOD: This review was carried out on reports drawn from Medline, Web of Science and SciELO. DISCUSSION: After the elucidation of the chemical structure of cannabidiol in 1…

The endocannabinoid-CB receptor system: Importance for development and in pediatric disease.

Authors: Ester Fride
Neuro endocrinology letters, February-April 2004

Endogenous cannabinoids (endocannabinoids) and their cannabinoid CB1 and CB2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism. Although most of these data are collected from animal studies, a role for cannab…

Cannabinoids and brain injury: therapeutic implications.

Authors: Raphael Mechoulam, David Panikashvili, Esther Shohami
Trends in Molecular Medicine, February 2002

Mounting in vitro and in vivo data suggest that the endocannabinoids anandamide and 2-arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have neuroprotective effects following brain injury. Cannabinoid receptor agonists inhibit glutamatergic synaptic tran…