The effects of Δ9-tetrahydrocannabinol on the dopamine system.

Authors: Michael A. P. Bloomfield, Abhishekh H. Ashok, Nora D. Volkow, Oliver D. Howes
Nature, 17 November 2016

The effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health. Patterns of cannabis use are changing drastically owing to legalization, the availability of synthetic analogues (commonly termed spice)…

Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis.

Authors: R. B. C. Kavia, D. De Ridder, C. S. Constantinescu, C. G. Stott, C. J. Fowler
Multiple Sclerosis Journal, November 2016

BACKGROUND: Bladder dysfunction is a common feature of multiple sclerosis (MS). OBJECTIVE: In this study we aimed to assess the efficacy, tolerability and safety of Sativex(®) (nabiximols) as an add-on therapy in alleviating bladder symptoms in patients with MS. METHODS: We un…