Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.

/by

Authors: Sara Ward, Michael Ramirez, Harshini Neelakantan, Ellen Walker
Anesthesia and Analgesia, October 2011
—
The taxane chemotherapeutic paclitaxel frequently produces peripheral neuropathy in humans. Rodent models to investigate mechanisms and treatments are largely restricted to male rats, whereas female mouse studies are lacking. We characterized a range of paclitaxel doses on col…

Read more

Cannabis use amongst patients with inflammatory bowel disease.

/by

Authors: Simon Lal, Neeraj Prasad, Manijeh Ryan, Sabrena Tangri, Mark Silverberg, et al
European Journal of Gastroenterology & Hepatology, October 2011
—
BACKGROUND: Experimental evidence suggests the endogenous cannabinoid system may protect against colonic inflammation, leading to the possibility that activation of this system may have a therapeutic role in inflammatory bowel disease (IBD). Medicinal use of cannabis for chron…

Read more

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.

/by

Authors: Érica M.Granjeiro, Felipe V.Gomes, Francisco S.Guimarães, Fernando M.A.Corrêa, Leonardo B.M. Resstel
Pharmacology Biochemistry and Behavior, October 2011
—
Systemic administration of cannabidiol (CBD), a non-psychotomimetic compound from Cannabis sativa, attenuates the cardiovascular and behavioral responses to restraint stress. Although the brain structures related to CBD effects are not entirely known, they could involve brains…

Read more