Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease.
Brain, January 2011
Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1 cannabinoid receptors. These receptors are highly abundant in the basal ganglia and play a pivotal role in the control of motor behaviour. An early downregulation of type 1 cannabinoid receptor…