Marijuana dependence and its treatment.

Authors: Alan J. Budney, Roger Roffman, Robert S. Stephens, Denise Walker
Addiction Science & Clinical Practice, December 2007

The prevalence of marijuana abuse and dependence disorders has been increasing among adults and adolescents in the United States. This paper reviews the problems associated with marijuana use, including unique characteristics of marijuana dependence, and the results of laborat…

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

Authors: Sean D. McAllister, Rigel T. Christian, Maxx P. Horowitz, Amaia Garcia, Pierre-Yves Desprez
Molecular Cancer Therapeutics, November 2007

Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clear…

Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine.

Authors: Ethan B. Russo, Geoffrey W. Guy, Philip J. Robson
Chemistry & Biodiversity, August 2007

Cannabis sativa L. has been utilized for treatment of pain and sleep disorders since ancient times. This review examines modern studies on effects of Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on sleep. It goes on to report new information on the effects on sleep…

Fitness to drive in spite (because) of THC.

Authors: Peter Strohbeck-Kühner, Gisela Skopp, Rainer Mattern
Archiv für Kriminologie, July-August 2007

Attention-deficit/hyperactivity disorder (ADHD) is characterized by a lack of concentration and/or an altered activation level. People with ADHD are found to violate traffic regulations, to commit criminal offences and to be involved in traffic accidents more often than the st…

Attenuation of allergic contact dermatitis through the endocannabinoid system.

Authors: Meliha Karsak, Evelyn Gaffal, Rahul Date, Lihua Wang-Eckhardt, Jennifer Rehnelt, et al
Science, 8 June 2007

Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors di…

Effects of marijuana smoking on pulmonary function and respiratory complications: a systematic review.

Authors: Jeanette M. Tetrault, Kristina Crothers, Brent A. Moore, Reena Mehra, et al
Archives of Internal Medicine, 12 February 2007

BACKGROUND: The relationship between marijuana smoking and pulmonary function or respiratory complications is poorly understood; therefore, we conducted a systematic review of the impact of marijuana smoking on pulmonary function and respiratory complications. METHODS: Studies…

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

Authors: Jonathan D. Wilkinson, Elizabeth M. Williamson
Journal of Dermatological Science, February 2007

BACKGROUND: Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and…