Cardiovascular and respiratory effects of cannabis in cat and rat.

Authors: J. D. P. Graham, D. M. F. Li
British Journal of Pharmacology, September 1973

1. In anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), Delta(1)-tetrahydrocannabinol (THC) (0.5 mg/kg) and Delta(6)-THC (0.5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate.2. Neither cannabinol (1 mg/kg, i.v…