Case Reports

SCC supports the practice of evidence-based cannabinoid medicine. This collection of research studies exists to guide clinical decision making. All included articles have been vetted by Board members to ensure that only rigorous, unbiased, and non-commercialized studies are included.


Entry ID20

Medical ConditionGastrointestinal disorders


Cannabidiol alleviates eosinophilic esophagitis
Medical Condition
Gastrointestinal disorders
Food gets stuck in throat
Gastrointestinal Disorders
Heartburn and reflux disease
Pain Scale: Before Cannabis Use
Pain Scale: After Cannabis Use
This 31-year-old white male with heartburn and dysphagia unresponsive to antacids was diagnosed with eosinophilic esophagitis. He finds relief of his symptoms by using cannabidiol rich concentrates.
Patient information
Brief history and target symptomatology
This 31-year-old computer security specialist developed heartburn around age 15, which did not respond to usual antacid treatment. 6 years later he developed severe dysphagia and was diagnosed with eosinophilic esophagitis upon esophagoscopy and biopsy. Recently he required bougienage for esophageal stricture. Cannabidiol rich concentrates relieve his dysphagia, without the need for additional medication.
Previous and current conventional therapies
Standard antacid therapy (Protonix, Nexium) did not relieve heartburn. He undergoes annual esophagoscopy and esophageal biopsy and recently required esophageal dilatation for stricture. He is currently in remission, for which he credits cannabidiol.
Clinical response to Cannabis
Relief of heartburn and dysphagia.
Additional Comments
Esophageal eosinophilia is increasingly recognized as a separate disease, with an incidence of one in 10,000 per year. Unlike GERD, it does not respond to antacids. It manifests with progressive dysphagia and may progress to esophageal stricture. It is usually associated with food allergies, however it may occur in antibody deficient patients. It is treated with dietary restrictions and topical corticosteroids, such as Flonase. The role of medical marijuana has not been investigated.


Here is a description of patient's method of using medical marijuana: “I do not use medical marijuana throughout the day, just at night, usually sometimes just before dinner to before bed, but almost never more than once in a day. I have used it twice after food has become lodged (and subsequently dislodged) to try to limit the additional swelling that usually occurs after such an event. With the use of medical marijuana, I have been able to return to, and finish my meal. My tolerance is quite low, so I have tried both vaporized plant and concentrate, and smoked plant, and low-dose lozenges and sprays. I cannot say for certain that one is any better than the other; all seem to help.”
Usual method of Cannabis administration
Frequency of Usage: Time Per Day
Frequency of Usage: Days per Week