Pain Measurements And Side Effect Profile Of The Novel Cannabinoid Ajulemic Acid

By | Chronic Pain, Endocannabinoid System, Inflammation, Neuropathy, Opioids, Pain, Research Articles

Cannabinoid AJA | Ajulemic Acid | Cannabis Pain Relief | Cannabis Anti-Inflammatory

In 2005, as published in the journal Neuropharmacology, researchers in Germany found pain relief in a synthetic cannabinoid called ajulemic acid. Synthetic modification of the THC metabolite THC-11-oic acid through replacement of the n-pentyl side chain with a dimethylheptyl group leads to the compound 1,1-dimethylheptyl-D8-THC-11-oic acid, named ajulemic acid (AJA) In preclinical studies AJA showed high analgesic potency comparable to morphine, as well as anti-allodynic and anti-inflammatory effects. AJA appears to have no detectable THC like psychoactive properties. Read More

CBD & Chemotherapy Induced Neuropathy

By | Cancer, CBD, Neuropathy, Research Articles

CBD for Chemotherapy Induced Neuropathy | CBD and Chemotherapy

Taxol is a common chemotherapy agent that is a mitotic inhibitor. It is used to treat patients with lung, ovarian, breast, head & neck cancer and advanced forms of Kaposi’s sarcoma. One of the painful side effects of this agent is neuropathy, a side effect that can limit the effective use of the drug. This article shows promise in using CBD to help prevent the neuropathy caused by Taxol. Read More

Cannabis for Opioid Harm Reduction

By | Chronic Pain, Neuropathy, Opioids, Pain, Research Articles

Cannabis for Opioid Harm Reduction | Cannabis and Opiates

Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning. The author suggests that physicians who treat neuropathic pain with opioids should evaluate their patients for a trial of cannabis and prescribe it when appropriate prior to using opioids. This harm reduction strategy may reduce the morbidity and mortality rates associated with prescription pain medications. Read More