Endocannabinoid System

Anandamide Inhibits Breast Tumor-Induced Angiogenesis

By | Anandamide, Breast Cancer, Cancer, Endocannabinoid System, Research Articles

Anandamide Inhibits Breast Tumor-Induced AngiogenesisEndocannabinoid Anandamide and Breast Cancer – more evidence. This 2014 study out of Italy, published in the journal Translational Medicine, found that following anandamide treatment, MDA-MB-231 cells lose their ability to stimulate endothelial cells proliferation in vitro, due to a significant inhibition of all the pro-angiogenic factors produced by these cells. This finding adds another piece of evidence to the anti-tumor efficacy of anandamide in breast cancer. Read More

Human Cannabinoid Receptor Gene Associated With Happiness

By | Behavioral Health, Endocannabinoid System, Research Articles

Human Cannabinoid Receptor Gene Associated With Happiness | Cannabis and Mood

This 2014 study out of Japan indicated that genetic traits, specifically the CB1 receptor gene genotypes, are closely related to happiness. C allele carriers of the SNP of CNR1 who are sensitive to positive emotional stimuli may experience a higher magnitude pleasure response when they experience positive events and may have a higher subjective happiness level. Read More

THC & Exercise Performance

By | Endocannabinoid System, Research Articles, THC

THC And Exercise Performance | THC Research

In a 2013 issue of the journal Nutrition & Metabolism, four drugs (ethanol, caffeine, nicotine & THC) were evaluated for their effect on exercise metabolism. Overall, it appears that cannabis does not have ergogenic potential in sports activities and thus, its inclusion on the banned list is likely a function of its illicitness. Read More

Cannabinoid Receptor Pharmacology

By | CBD, Endocannabinoid System, Research Articles, THC, THCV

Cannabinoid Receptor Pharmacology | Cannabinoid Receptor Agonists

Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids or phytocannabinoids. This review published in 2008 in the Journal of British Pharmacology focuses on the manner with which three of these compounds, (_)-trans-D9-tetrahydrocannabinol (D9-THC), (_)-cannabidiol (CBD) and (_)-trans-D9-tetrahydrocannabivarin (D9-THCV), interact with cannabinoid receptors CB1 and CB2. Read More

Pain Measurements And Side Effect Profile Of The Novel Cannabinoid Ajulemic Acid

By | Chronic Pain, Endocannabinoid System, Inflammation, Neuropathy, Opioids, Pain, Research Articles

Cannabinoid AJA | Ajulemic Acid | Cannabis Pain Relief | Cannabis Anti-Inflammatory

In 2005, as published in the journal Neuropharmacology, researchers in Germany found pain relief in a synthetic cannabinoid called ajulemic acid. Synthetic modification of the THC metabolite THC-11-oic acid through replacement of the n-pentyl side chain with a dimethylheptyl group leads to the compound 1,1-dimethylheptyl-D8-THC-11-oic acid, named ajulemic acid (AJA) In preclinical studies AJA showed high analgesic potency comparable to morphine, as well as anti-allodynic and anti-inflammatory effects. AJA appears to have no detectable THC like psychoactive properties. Read More

Cannabinoids Reduce ErbB2-driven Breast Cancer Progression

By | Cancer, Endocannabinoid System, Research Articles

Cannabinoids in ErbB2 Breast Cancer | Cannabis Breast Cancer

ErbB2-overexpressing breast tumors are characterized by very aggressive clinical courses and decreased survival rates, mostly due to the poorly differentiated, highly proliferative and highly invasive nature of their constituent cells. From Italy comes this research, published in Molecular Cancer in 2010, sharing findings which suggest that these highly aggressive and low responsive tumors could be efficiently treated with non-psychoactive CB2-selective agonists without affecting the surrounding healthy tissue. Read More

Endocannabinoid System Removes Damaged Brain Cells, Improves Mitochondrial Health

By | Brain Health, Endocannabinoid System, Research Articles

Endocannabinoid System Removes Damaged Cells, Improves Mitochondrial Health

This December 2012 review, published in Philosophical Transactions of the Royal Society B out of Germany, suggests that activating the brain’s cannabinoid system may trigger a sort of anti-oxidant cleanse, removing damaged cells and improving the efficiency of the mitochrondria, the energy source that powers cells, ultimately leading to a more robustly functioning brain. Read More