CBD Controls Breast Cancer Aggressiveness

By | Cancer, CBD, Research Articles

CBD Controls Breast Cancer AggressivenessPublished in September 2011 in the journal Breast Cancer Research and Treatment, Sean McAllister et all described CBD interacting through a cellular system that regulates the expression of key transcriptional factors (e.g., Id-1) that control breast cancer cell proliferation, migration, and invasion. Read More

Cannabidiol As A Novel Inhibitor Of Id-1 Gene Expression In Aggressive Breast Cancer Cells

By | Cancer, CBD, Research Articles

CBD Inhibits Metastatic Breast Cancer Cell Gene Expression

CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness. In 2007, at the California Pacific Medical Center Research Institute, a study was published by Sean McAllister in the journal Molecular Cancer Therapeutics titled: Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Read More

CBD Protects Against Myocardial Ischemic Reperfusion

By | CBD, Heart Health, Research Articles

CBD Protects Against Myocardial Ischemic Reperfusion

From the American Journal of Physiology – Heart and Circulatory Physiology published in September 2007, research from Israel has shown that CBD causes reduced infarct size in an in vivo rat model of ischemia and reperfusion. Furthermore, it seems that this effect is not direct and may be mediated by a reduced inflammatory response. Thus CBD may be a promising novel treatment for myocardial ischemia. Read More

Cannabis And HIV Infection

By | CBD, HIV, Research Articles

Cannabinoids May inhibit HIV in Late-Stage AIDS

Mount Sinai School of Medicine researchers discovered that cannabis-like chemicals trigger receptors on human immune cells that can directly inhibit a type of human immunodeficiency virus (HIV) found in late-stage AIDS, according to findings published online in March of 2012 in the journal PLoS ONE. Triggering CB1 causes the drug high associated with cannabis, making it undesirable for physicians to prescribe. The researchers wanted to explore therapies that would target CB2 only. The Mount Sinai team infected healthy immune cells with HIV, then treated them with a chemical that triggers CB2 called an agonist. They found that the drug reduced the infection of the remaining cells. Read More

Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology

By | CBD, Research Articles, THC

THC and CBD have Opposite Effects on Brain and Body

Can CBD counteract adverse effects of excessive THC? In this 2010 issue of the journal Neuropsychopharmacology, they showed that pretreatment with CBD prevented the acute induction of psychotic symptoms by D-9-tetrahydrocannabinol. D-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD’s ability to block the psychotogenic effects of D-9-THC. Read More

Cannabidiol: From an Inactive Cannabinoid to a Drug with Wide Spectrum of Action

By | Alzheimer's Disease, Arthritis, Cancer, CBD, Diabetes, Nausea, Research Articles

CBD Health Benefits for Parkinson's, Diabetes, and More

The years 2003 – 2008 showed a remarkable increase in publications on cannabidiol mainly stimulated by the discovery of its anti-inflammatory, anti-oxidative and neuroprotective effects. These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson’s disease, Alzheimer’s disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer. Read More