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Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use.

By | CBD, Drug Interactions

Authors: Joshua D. Brown, Almut G. Winterstein
Journal of Clinical Medicine, 8 July 2019

Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects and associated adverse drug events (ADEs) along with the potential for pharmacokinetic and pharm…

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Cannabidiol Adverse Effects and Toxicity.

By | CBD

Authors: Marilyn A. Huestis, Renata Solimini, Simona Pichini, Roberta Pacifici, et al
Current Neuropharmacology, 3 June 2019

BACKGROUND: Currently, there is great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. M…

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Cannabinoid Receptor Pharmacology

By | CBD, Endocannabinoid System, Research Articles, THC, THCV

Cannabinoid Receptor Pharmacology | Cannabinoid Receptor Agonists

Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids or phytocannabinoids. This review published in 2008 in the Journal of British Pharmacology focuses on the manner with which three of these compounds, (_)-trans-D9-tetrahydrocannabinol (D9-THC), (_)-cannabidiol (CBD) and (_)-trans-D9-tetrahydrocannabivarin (D9-THCV), interact with cannabinoid receptors CB1 and CB2. Read More

CBD Protects Against Myocardial Ischemic Reperfusion

By | CBD, Heart Health, Research Articles

CBD Protects Against Myocardial Ischemic Reperfusion

From the American Journal of Physiology – Heart and Circulatory Physiology published in September 2007, research from Israel has shown that CBD causes reduced infarct size in an in vivo rat model of ischemia and reperfusion. Furthermore, it seems that this effect is not direct and may be mediated by a reduced inflammatory response. Thus CBD may be a promising novel treatment for myocardial ischemia. Read More

Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology

By | CBD, Research Articles, THC

THC and CBD have Opposite Effects on Brain and Body

Can CBD counteract adverse effects of excessive THC? In this 2010 issue of the journal Neuropsychopharmacology, they showed that pretreatment with CBD prevented the acute induction of psychotic symptoms by D-9-tetrahydrocannabinol. D-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD’s ability to block the psychotogenic effects of D-9-THC. Read More