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HIV Infections

Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.

By | HIV Infections, Viruses

Authors: Cristina Maria Costantino, Achla Gupta, Alice W. Yewdall, Benjamin M. Dale, et al
PLoS One, 2012

Agents that activate cannabinoid receptor pathways have been tested as treatments for cachexia, nausea or neuropathic pain in HIV-1/AIDS patients. The cannabinoid receptors (CB(1)R and CB(2)R) and the HIV-1 co-receptors, CCR5 and CXCR4, all signal via Gαi-coupled pathways. We…

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