Category

Neurodegenerative Diseases

Endocannabinoid system in neurodegenerative disorders.

By | Neurodegenerative Diseases

Authors: Balapal S. Basavarajappa, Madhu Shivakumar, Vikram Joshi, Shivakumar Subbanna
Journal of Neurochemistry, September 2017

Most neurodegenerative disorders (NDDs) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression of these NDDs are not well-defined. Several mechanisms have been proposed to contribute to the develo…

Read More

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

By | Brain Disorders, Huntington Disease, Nervous System Diseases, Neurodegenerative Diseases

Authors: Javier Fernández‐Ruiz, Onintza Sagredo, M. Ruth Pazos, Concepción García, Roger Pertwee, et al
British Journal of Clinical Pharmacology, February 2013

Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, an…

Read More

The endocannabinoid system in normal and pathological brain ageing.

By | Nervous System Diseases, Neurodegenerative Diseases

Authors: Andras Bilkei-Gorzo
Philosophical Transactions of the Royal Society B: Biological Sciences, 5 December 2012

The role of endocannabinoids as inhibitory retrograde transmitters is now widely known and intensively studied. However, endocannabinoids also influence neuronal activity by exerting neuroprotective effects and regulating glial responses. This review centres around this less-s…

Read More