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Schizophrenia Spectrum

Cannabis Use and Hypomania in Young People: A Prospective Analysis .

By | Behavioral Health, Schizophrenia Spectrum

Authors: Steven Marwaha, Catherine Winsper, Paul Bebbington, Daniel Smith
Schizophrenia Bulletin, November 2018

Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with…

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Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.

By | Behavioral Health, Bipolar Disorders, Schizophrenia Spectrum, Substance-Related Disorders

Authors: Marie Stefanie Kejser Starzer, Merete Nordentoft, Carsten Hjorthøj
American Journal of Psychiatry, April 2018

OBJECTIVE: The authors investigated the rates of conversion to schizophrenia and bipolar disorder after a substance-induced psychosis, as well as risk factors for conversion. METHOD: All patient information was extracted from the Danish Civil Registration System and the Psychi…

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Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis.

By | Behavioral Health, Schizophrenia Spectrum

Authors: Antti Mustonen, Solja Niemelä, Tanja Nordström, Graham K. Murray, Pirjo Mäki, et al
The British Journal of Psychiatry, April 2018

BACKGROUND: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial. Aims To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodro…

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The Potential of Cannabidiol Treatment for Cannabis Users With Recent-Onset Psychosis.

By | Behavioral Health, Schizophrenia Spectrum, Substance-Related Disorders

Authors: Britta Hahn
Schizophrenia Bulletin, 13 January 2018

A major factor associated with poor prognostic outcome after a first psychotic break is cannabis misuse, which is prevalent in schizophrenia and particularly common in individuals with recent-onset psychosis. Behavioral interventions aimed at reducing cannabis use have been un…

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Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study.

By | Behavioral Health, Schizophrenia Spectrum

Authors: Marta Di Forti, Arianna Marconi, Elena Carra, Sara Fraietta, Antonella Trotta, Matteo Bonomo, et al
The Lancet Psychiatry, March 2015

BACKGROUND: The risk of individuals having adverse effects from drug use (eg, alcohol) generally depends on the frequency of use and potency of the drug used. We aimed to investigate how frequent use of skunk-like (high-potency) cannabis in south London affected the associatio…

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A controlled family study of cannabis users with and without psychosis.

By | Behavioral Health, Schizophrenia Spectrum

Authors: Ashley C. Proal, Jerry Fleming, Juan A. Galvez-Buccollini, Lynn E. DeLisi
Schizophrenia Research, January 2014

BACKGROUND: Cannabis is one of the most highly abused illicit drugs in the world. Several studies suggest a link between adolescent cannabis use and schizophrenia. An understanding of this link would have significant implications for legalization of cannabis and its medicinal…

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Does using marijuana increase the risk for developing schizophrenia?

By | Behavioral Health, Schizophrenia Spectrum, Substance-Related Disorders

Authors: A. Eden Evins, Alan I. Green, John M. Kane, Sir Robin M. Murray
The Journal of Clinical Psychiatry, April 2013

As more US states and other countries consider legalizing marijuana, clinicians need to know the possible effects of this drug. Research has shown a connection between marijuana use and an increased risk for schizophrenia in young people who are vulnerable to developing psycho…

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Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.

By | Behavioral Health, Schizophrenia Spectrum

Authors: F. M. Leweke, D. Piomelli, F. Pahlisch, D. Muhl, C. W. Gerth, C. Hoyer, J. Klosterkötter, et al
Translational Psychiatry, 20 March 2012

Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide. We previously reported that an elevation of anandamide levels in cerebrospinal fluid inversely correlated to psychot…

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Potential protective effects of cannabidiol on neuroanatomical alterations in cannabis users and psychosis: a critical review.

By | Behavioral Health, Schizophrenia Spectrum, Substance-Related Disorders

Authors: Derik Hermann , Miriam Schneider
Current Pharmaceutical Design, 2012

Cannabis use and the development of schizophrenic psychoses share a variety of similarities. Both start during late adolescence; go along with neuropsychological deficits, reduced activity, motivation deficits, and hallucinations suggesting impairment of similar brain structur…

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If cannabis caused schizophrenia–how many cannabis users may need to be prevented in order to prevent one case of schizophrenia? England and Wales calculations.

By | Behavioral Health, Schizophrenia Spectrum, Substance-Related Disorders

Authors: Matt Hickman, Peter Vickerman, John Macleod, Glyn Lewis, Stan Zammit, et al
Addiction, November 2009

BACKGROUND: We consider how many cannabis users may need to be prevented in order to prevent one case of schizophrenia or psychosis [defined as number needed to prevent (NNP)]. METHOD: Calculation for England and Wales using best available estimates of: incidence of schizophre…

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