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Behavior & Behavior Mechanisms

Medical marijuana laws and suicides by gender and age.

By | Behavior & Behavior Mechanisms, Medical Cannabis, Suicide

Authors: D. Mark Anderson, Daniel I. Rees, Joseph J. Sabia
American Journal of Public Health, December 2014

OBJECTIVES: We estimated the association between legalizing medical marijuana and suicides. METHODS:
We obtained state-level suicide data from the National Vital Statistics System’s Mortality Detail Files for 1990-2007. We used regression analysis to examine the association be…

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Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.

By | Anxiety, Behavior & Behavior Mechanisms

Authors: R J Bluett, J C Gamble-George, D J Hermanson, N D Hartley, L J Marnett, S Patel
Translational Psychiatry, 8 July 2014

Stress is a major risk factor for the development of mood and anxiety disorders; elucidation of novel approaches to mitigate the deleterious effects of stress could have broad clinical applications. Pharmacological augmentation of central endogenous cannabinoid (eCB) signaling…

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Genetic variations in the human cannabinoid receptor gene are associated with happiness.

By | Behavior & Behavior Mechanisms, Clinical Endocannabinoid Deficiency, Happiness

Authors: Masahiro Matsunaga , Tokiko Isowa, Kaori Yamakawa, Seisuke Fukuyama, Jun Shinoda, et al
PLoS One, 1 April 2014

Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level). As previous studies demonstrated that individuals with high subjective happiness level rated their current affective states more…

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The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD).

By | Anxiety, Behavior & Behavior Mechanisms, Behavioral Health, Stress Disorders - Post-Traumatic

Authors: Viviana Trezza, Patrizia Campolongo
Frontiers in Behavioral Neuroscience, 9 August 2013

Post-traumatic stress disorder (PTSD) is a psychiatric disorder of significant prevalence and morbidity, whose pathogenesis relies on paradoxical changes of emotional memory processing. An ideal treatment would be a drug able to block the pathological over-consolidation and co…

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Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence.

By | Anxiety, Behavior & Behavior Mechanisms, Behavioral Health, Stress Disorders - Post-Traumatic

Authors: Torsten Passie, Hinderk M. Emrich, Matthias Karst, Simon D. Brandt, John H. Halpern
Drug Testing and Analysis, July-August 2012

It is known from clinical studies that some patients attempt to cope with the symptoms of post-traumatic stress disorder (PTSD) by using recreational drugs. This review presents a case report of a 19-year-old male patient with a spectrum of severe PTSD symptoms, such as intens…

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Prescribing cannabis for harm reduction.

By | Behavior & Behavior Mechanisms, Harm Reduction, Opioids, Pain, Substance-Related Disorders

Authors: Mark Collen
Harm Reduction Journal, 1 January 2012

Neuropathic pain affects between 5% and 10% of the US population and can be refractory to treatment. Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without…

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Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.

By | Behavior & Behavior Mechanisms, Stress - Psychological

Authors: Érica M.Granjeiro, Felipe V.Gomes, Francisco S.Guimarães, Fernando M.A.Corrêa, Leonardo B.M. Resstel
Pharmacology Biochemistry and Behavior, October 2011

Systemic administration of cannabidiol (CBD), a non-psychotomimetic compound from Cannabis sativa, attenuates the cardiovascular and behavioral responses to restraint stress. Although the brain structures related to CBD effects are not entirely known, they could involve brains…

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Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.

By | Anxiety, Behavior & Behavior Mechanisms

Authors: A. W. Zuardi, I. Shirakawa, E. Finkelfarb, I. G. Karniol
Psychopharmacology, DATE

The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements an…

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