Entries by Danielle Russell

Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.

Authors: Juhn A. Wada, Akira Wake, Mitsumoto Sato, Michael E. Corcoran
Epilepsia, September 1975

Acute administration of delta8-tetrahydrocannabinol (delta8-THC) or delta9-THC failed to affect partially developed or fully developed kindled amygdaloid seizures in cats. However, delta9-THC was quite effective in suppressing focal AD in the stimulated amygdala when administe…

Antitussive activity of some naturally occurring cannabinoids in anesthetized cats.

Authors: Robert Gordon, Robert J.Gordon, R.Duane Sofia
European Journal of Pharmacology, February 1976

Experimental cough was elicited in pentobarbital-anesthetized cats by either electrical stimulation of the superior laryngeal nerve or by mechanical stimulation of the tracheal mucosa. Intravenous administration of delta9-tetrahydrocannabinol (THC) effectively reduced the ampl…

Pharmacokinetics of delta9-tetrahydrocannabinol in dogs.

Authors: Edward R. Garrett, Edward R. Garrett, C. Anthony Hunt
Journal of Pharmaceutical Sciences, March 1977

The pharmacokinetics of intravenously administered 14C-delta9-tetrahydrocannabinol and derived radiolabeled metabolites were studied in three dogs at two doses each at 0.1 or 0.5 and 2.0 mg/kg. Two dogs were biliary cannulated; total bile was collected in one and sampled in th…

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.

Authors: Jomar M. Cunha, E.A. Carlini, Aparecido E. Pereira, Oswaldo L. Ramos, Camilo Pimentel, et al
Pharmacology, 1980

In phase 1 of the study, 3 mg/kg daily of cannabidiol (CBD) was given for 30 days to 8 health human volunteers. Another 8 volunteers received the same number of identical capsules containing glucose as placebo in a double-blind setting. Neurological and physical examinations…

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Hypnotic and antiepileptic effects of cannabidiol.

Authors: Elisaldo A. Carlini, Jomar M. Cunha
The Journal of Clinical Pharmacology, August-September 1981

Clinical trials with cannabidiol (CBD) in healthy volunteers, isomniacs, and epileptic patients conducted in the authors’ laboratory from 1972 up to the present are reviewed. Acute doses of cannabidiol ranging from 10 to 600 mg and chronic administration of 10 mg for 20 days o…

Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.

Authors: A. W. Zuardi, I. Shirakawa, E. Finkelfarb, I. G. Karniol
Psychopharmacology, DATE

The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements an…

Pharmacokinetics of cannabidiol in dogs.

Authors: E Samara, M Bialer, R Mechoulam
Drug Metabolism and Disposition: The Biological Fate of Chemicals, May/June 1988

Cannabidiol (CBD) is one of the major nonpsychoactive cannabinoids produced by Cannabis sativa L. Recent studies have shown that CBD has a high protective index, comparable to that of phenobarbital and phenytoin. Because CBD has been reported to possess both anticonvulsant and…

Poor and pregnant: perinatal ganja use in rural Jamaica.

Authors: Melanie C. Dreher
Advances in Alcohol & Substance Abuse, 1989

This paper reports the ethnographic findings from a study of cannabis use by pregnant women in rural Jamaica. The perceived functions of ganja in reducing the physiological symptoms of pregnancy and associated psychological stress are described in relation to the sociocultural…

Cannabinoid receptor localization in brain.

Authors: M Herkenham, A B Lynn, M D Little, M R Johnson, L S Melvin, B R de Costa, K C Rice
Proceedings of the National Academy of Sciences, March 1990

[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor in brain sections. The potencies of a series of natural and synthetic cannabi…

Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy.

Authors: Jill S. Hayes, R Lampart, Melanie C Dreher, Lisa Morgan
The West Indian medical journal, September 1991

This research provides data on the development of 59 Jamaican children, from birth to age 5 years, whose mothers used marijuana during pregnancy. Approximately one-half of the sample used marijuana during pregnancy and were matched with non-users according to age, parity, and…