Category

Research Articles

Treatment of Crohn’s Disease with Cannabis

By | Crohn's Disease, Research Articles

Treatment of Crohn’s Disease with Cannabis: an Observational StudyIn 2011, researchers in Israel published the first study evaluating the effect of cannabis on patients with Crohn’s disease. All patients stated that consuming cannabis had a positive effect, ameliorating disease activity and reducing the need for other conventional medications. The researchers hypothesized that the observed beneficial effect in this study may be due to the anti-inflammatory properties of cannabis, but additional effects of cannabinoids may also play a role. Read More

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

By | Research Articles

Efficacy of Inhaled Cannabis on Painful Diabetic NeuropathyResearchers at the University of California, San Diego performed a randomized, double-blinded, placebo controlled crossover study in 16 patients with painful diabetic peripheral neuropathy to assess the short-term efficacy and tolerability of inhaled cannabis. This trial of inhaled cannabis demonstrated a dose-dependent reduction in diabetic peripheral neuropathy pain in patients with treatment-refractory pain. This adds preliminary evidence to support further research on the efficacy of cannabinoids in neuropathic pain. Read More

Cannabinoid–Opioid Interaction in Chronic Pain

By | Chronic Pain, Opioids, Research Articles

Cannabinoid Opioid Interaction in Chronic PainIn 2011, Nature Publishing Group released an article by researchers at the University of California, San Francisco, who undertook a study of twenty-one individuals with chronic pain to delineate the synergistic effects of cannabinoids and opioids. The study concluded that vaporized cannabis augments the analgesic effects of opioids without significantly altering plasma opioid levels. The combination may allow for opioid treatment at lower doses with fewer side effects. Read More

Endocannabinoid Signaling in Autism

By | Autism, Endocannabinoid System, Research Articles

Endocannabinoid Signaling in AutismIn July 2015, Neurotherapeutics published an article about Autism spectrum disorder (ASD), presenting a modern view of the endocannabinoid (eCB) system, and alterations of its main components in human patients and animal models relevant to ASD. Our understanding of eCB signaling in autism is still in its infancy compared with other disorders of the central nervous system or of peripheral tissues, where eCB-based therapies have already reached preclinical and clinical phases. However, research in this field is rapidly evolving, and novel drugs able to hit specifically a distinct element of the eCB system are being developed at a surprising speed. Read More

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells

By | Breast Cancer, CBD, Research Articles

Cannabidiol Induces Programmed Cell Death in Breast Cancer CellsA study by researchers at Harvard Medical School was published in Molecular Cancer Therapeutics in 2011 characterizing the mechanism underlying the antitumoral properties of cannabidiol (CBD). This study showed that CBD induced both apoptosis and autophagy-induced death in breast cancer cells and inhibited the survival of both estrogen receptor-positive and estrogen receptor-negative breast cancer cell lines. These data enhance the desirability of CBD as an anticancer agent, because they suggest that CBD preferentially kills breast cancer cells, while minimizing damage to normal breast tissue.
Read More

Cannabidiol Inhibits Human Glioma Cell Migration

By | Brain Health, Cancer, CBD, Research Articles

CaCannabidiol Inhibits Human Glioma Cell MigrationIn 2005, the British Journal of Pharmacology published a study evaluating the ability of cannabidiol (CBD) to impair the migration of tumor cells and thus act as a potential antitumoral compound. The results of the study reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. This antimigratory property, together with the known antiproliferative and apoptotic features of CBD, strengthen the evidence for its use as a potential antitumoral agent.
Read More